Implication of complement system and its regulators in Alzheimer's Disease

Kolev, Martin ORCID: https://orcid.org/0000-0002-7208-3875, Ruseva, Marieta Milkova, Harris, Claire Louise, Morgan, Bryan Paul ORCID: https://orcid.org/0000-0003-4075-7676 and Donev, Rossen Mintchev 2009. Implication of complement system and its regulators in Alzheimer's Disease. Current Neuropharmacology 7 (1) , pp. 1-8.

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Abstract

Alzheimer's disease (AD) is an age-related neurodegenerative disease that affects approximately 24 million people worldwide. A number of different risk factors have been implicated in AD, however, neuritic (amyloid) plaques are considered as one of the defining risk factors and pathological hallmarks of the disease. Complement proteins are integral components of amyloid plaques and cerebral vascular amyloid in Alzheimer brains. They can be found at the earliest stages of amyloid deposition and their activation coincides with the clinical expression of Alzheimer's dementia. This review emphasizes on the dual key roles of complement system and complement regulators (CRegs) in disease pathology and progression. The particular focus of this review is on currently evolving strategies for design of complement inhibitors that might aid therapy by restoring the fine balance between activated components of complement system, thus improving the cognitive performance of patients. This review discusses these issues with a view to inspiring the development of new agents that could be useful for the treatment of AD.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	Alzheimer's disease, neurodegeneration, inflammation, β-amyloid peptide, complement, complement regulators, CD59, complement therapeutics
Publisher:	Bentham Science Publishers
ISSN:	1570-159X
Last Modified:	18 Oct 2022 14:31
URI:	https://orca.cardiff.ac.uk/id/eprint/17825

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