Davies, Kate  ORCID: https://orcid.org/0000-0002-9807-1231, Rizek, Al-Motaz, Edkins, Sarah ORCID: https://orcid.org/0000-0003-0717-1972, Kollnberger, Simon, Wang, Eddie C. Y. ORCID: https://orcid.org/0000-0002-2243-4964, Eberl, Matthias ORCID: https://orcid.org/0000-0002-9390-5348, Underwood, Jonathan ORCID: https://orcid.org/0000-0001-6963-2821 and Mclaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934
2025.
NKG2A-mediated immune modulation of natural killer cells by Staphylococcus aureus.
The Journal of Immunology
214
(12)
, pp. 3332-3344.
10.1093/jimmun/vkaf174
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Abstract
Natural killer (NK) cells are specialized lymphocytes that help protect against viruses and cancer. However, in the context of bacterial infections, NK cells can be harmful, rather than protective. Such immune pathogenesis by NK cells has been linked to the overproduction of proinflammatory cytokines like interferon-gamma (IFN-γ). In this context, IFN-γ–deficient mice display increased survival rates in response to Staphylococcus aureus (S. aureus) infection. However, little is known about how NK cells respond to S. aureus in humans, which causes life-threatening, invasive systemic infections with high mortality rates. In this study, we found that the peripheral blood of patients with bloodstream S. aureus infection was enriched for CD57− NKG2A+ NK cells with greater cytokine-producing capacity, compared to healthy controls and those hospitalized with Escherichia coli bloodstream infections. As a possible mechanistic cause, superantigens from S. aureus promoted the expansion of CD57− NKG2A+ NK cells that produced IFN-γ through a mechanism that appears to be IL-12 independent and exhibited reduced levels of CD16 compared to unstimulated NK cells. These data suggest that S. aureus bloodstream infection in humans promotes a phenotypic shift toward CD57− NKG2A+ NK cells with greater IFN-γ–producing capacity, providing a plausible way to promote inflammation-driven disease pathogenesis.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine Research Institutes & Centres > Systems Immunity Research Institute (SIURI) |
| Publisher: | American Association of Immunologists |
| ISSN: | 0022-1767 |
| Date of First Compliant Deposit: | 26 June 2025 |
| Date of Acceptance: | 11 June 2025 |
| Last Modified: | 15 Jan 2026 11:37 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/179239 |
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