Auguries of adaptivity: LES γδ TCR ligand recognition revisited

Gunn, Juliet L., Rubina, Anzelika, Fielding, Ceri A. ORCID: https://orcid.org/0000-0002-5817-3153, Mohammed, Fiyaz, Wang, Eddie C.Y. ORCID: https://orcid.org/0000-0002-2243-4964, Willcox, Carrie R. and Willcox, Benjamin E. 2025. Auguries of adaptivity: LES γδ TCR ligand recognition revisited. Trends in Immunology 10.1016/j.it.2025.10.006

Full text not available from this repository.

Abstract

Identification of antigenic ligands for the γδ T cell receptor (TCR) has remained a highly challenging goal since the emergence in the 1980s of γδ T cells as a distinct immune compartment. In a significant advance more than 12 years ago, endothelial protein C receptor (EPCR), a cell-surface-expressed major histocompatibility complex (MHC)-like protein that binds phospholipids, was identified as the first ligand for a human γδ TCR to be validated by direct binding experiments: a finding that undoubtedly posed more questions than it answered. In this review we discuss how features of this single clonotypic specificity anticipated insights into adaptive-like human γδ T cell biology that emerged in subsequent investigations, and we highlight recent findings about EPCR that point towards the relevance of such responses in anti-pathogen and potentially anti-tumour immunity.

Item Type:	Article
Date Type:	Published Online
Status:	In Press
Schools:	Schools > Medicine
Publisher:	Cell Press
ISSN:	1471-4906
Last Modified:	08 Dec 2025 16:30
URI:	https://orca.cardiff.ac.uk/id/eprint/182993

Actions (repository staff only)

Edit Item