Gunn, Juliet L., Rubina, Anzelika, Fielding, Ceri A.  ORCID: https://orcid.org/0000-0002-5817-3153, Mohammed, Fiyaz, Wang, Eddie C.Y. ORCID: https://orcid.org/0000-0002-2243-4964, Willcox, Carrie R. and Willcox, Benjamin E.
2025.
Auguries of adaptivity: LES γδ TCR ligand recognition revisited.
Trends in Immunology
10.1016/j.it.2025.10.006
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Abstract
Identification of antigenic ligands for the γδ T cell receptor (TCR) has remained a highly challenging goal since the emergence in the 1980s of γδ T cells as a distinct immune compartment. In a significant advance more than 12 years ago, endothelial protein C receptor (EPCR), a cell-surface-expressed major histocompatibility complex (MHC)-like protein that binds phospholipids, was identified as the first ligand for a human γδ TCR to be validated by direct binding experiments: a finding that undoubtedly posed more questions than it answered. In this review we discuss how features of this single clonotypic specificity anticipated insights into adaptive-like human γδ T cell biology that emerged in subsequent investigations, and we highlight recent findings about EPCR that point towards the relevance of such responses in anti-pathogen and potentially anti-tumour immunity.
| Item Type: | Article |
|---|---|
| Date Type: | Published Online |
| Status: | In Press |
| Schools: | Schools > Medicine |
| Publisher: | Cell Press |
| ISSN: | 1471-4906 |
| Date of First Compliant Deposit: | 18 December 2025 |
| Date of Acceptance: | 14 October 2025 |
| Last Modified: | 18 Dec 2025 12:30 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/182993 |
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