Lipid classes and fatty acid patterns are altered in the brain of γ-synuclein null mutant mice

Guschina, Irina, Millership, Steven, O'Donnell, Valerie Bridget ORCID: https://orcid.org/0000-0003-4089-8460, Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648, Harwood, John ORCID: https://orcid.org/0000-0003-2377-2612 and Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 2011. Lipid classes and fatty acid patterns are altered in the brain of γ-synuclein null mutant mice. Lipids 46 (2) , pp. 121-130. 10.1007/s11745-010-3486-0

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Abstract

The well-documented link between α-synuclein and the pathology of common human neurodegenerative diseases has increased attention to the synuclein protein family. The involvement of α-synuclein in lipid metabolism in both normal and diseased nervous system has been shown by many research groups. However, the possible involvement of γ-synuclein, a closely-related member of the synuclein family, in these processes has hardly been addressed. In this study, the effect of γ-synuclein deficiency on the lipid composition and fatty acid patterns of individual lipids from two brain regions has been studied using a mouse model. The level of phosphatidylserine (PtdSer) was increased in the midbrain whereas no changes in the relative proportions of membrane polar lipids were observed in the cortex of γ-synuclein-deficient compared to wild-type (WT) mice. In addition, higher levels of docosahexaenoic acid were found in PtdSer and phosphatidylethanolamine (PtdEtn) from the cerebral cortex of γ-synuclein null mutant mice. These findings show that γ-synuclein deficiency leads to alterations in the lipid profile in brain tissues and suggest that this protein, like α-synuclein, might affect neuronal function via modulation of lipid metabolism.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Systems Immunity Research Institute (SIURI)
Subjects:	Q Science > Q Science (General)
Uncontrolled Keywords:	lipid composition; synuclein; midbrain; cortex; phosphatidylserine; docosahexaenoic acid; γ-synuclein null mutant mice
Publisher:	Springer
ISSN:	0024-4201
Last Modified:	31 Jan 2025 22:22
URI:	https://orca.cardiff.ac.uk/id/eprint/18766

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