IgM multiple myeloma: a diagnostic challenge in a patient with coexisting chronic lymphocytic leukaemia

Hewamana, Saman, Pepper, Christopher John, Couzens, Stephen, Thomas, Alun and Knapper, Steven ORCID: https://orcid.org/0000-0002-6405-4441 2008. IgM multiple myeloma: a diagnostic challenge in a patient with coexisting chronic lymphocytic leukaemia. International Journal of Hematology 88 (4) , pp. 424-427. 10.1007/s12185-008-0179-z

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Abstract

As IgM multiple myeloma is a rare poorly characterised disease entity; there is only limited published data on its clinical, microscopic and immunophenotypic features. We report a 72-year-old man misdiagnosed as Waldenström’s macroglobulinemia. Also the diagnosis was further complicated by coexisting chronic lymphocytic leukaemia. Following confirmation of IgM myeloma, in view of the patient’s deteriorating clinical condition; he was entered into the UK Medical Research Council Myeloma IX trial where he had partial response to chemotherapy. This case highlights the value of detailed immunophenotypic evaluation when clinical and morphological markers are equivocal.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords:	Multiple myeloma, Waldastroms macroglobulinaemia, CLL, Diagnositic tests, Immunophenotyping
Publisher:	Springer
ISSN:	0925-5710
Last Modified:	06 Jan 2024 02:26
URI:	https://orca.cardiff.ac.uk/id/eprint/23655

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