Lewis, Ruth D., Jackson, Christopher L., Morgan, Bryan Paul  ORCID: https://orcid.org/0000-0003-4075-7676 and Hughes, Timothy Richard ORCID: https://orcid.org/0000-0003-2348-3490
2010.
The membrane attack complex of complement drives the progression of atherosclerosis in apolipoprotein E knockout mice.
Molecular Immunology
47
(5)
, pp. 1098-1105.
10.1016/j.molimm.2009.10.035
|
Abstract
AIMS: To examine the roles of the membrane attack complex of complement and its sole membrane regulator, CD59, in atherosclerosis. METHODS: C6 (C6(-/-)) deficient and CD59a (Cd59a(-/-)) knockout mice were separately crossed onto the apolipoprotein E knockout (apoE(-/-)) background. The double knockout mice were fed high-fat diet in order to study the effects of absence of C6 or CD59a on the progression of atherosclerosis. RESULTS: C6 deficiency significantly reduced plaque area and disease severity. CD59a had the opposite effect in that deficiency was associated with a significant increase in plaque area, correlating with increased membrane attack complex (MAC) deposition in the plaque and increased smooth muscle cell proliferation in early plaques. CONCLUSIONS: Our results demonstrate that the MAC contributes to the development of atherosclerosis, C6 deficiency being protective and CD59a deficiency exacerbating disease.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Medicine |
| Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RM Therapeutics. Pharmacology |
| Uncontrolled Keywords: | Atherosclerosis; Complement; Membrane attack complex; Apolipoprotein E knockout mouse |
| Publisher: | Elsevier |
| ISSN: | 0161-5890 |
| Last Modified: | 06 Dec 2022 09:43 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/25598 |
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