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IL-10 restricts memory T cell inflation during cytomegalovirus infection

Jones, Morgan, Ladell, Kristin Ingrid ORCID:, Wynn, Katherine, Stacey, Maria A., Quigley, Maire F., Gostick, Emma, Price, David ORCID: and Humphreys, Ian R. ORCID: 2010. IL-10 restricts memory T cell inflation during cytomegalovirus infection. The Journal of Immunology 185 (6) , pp. 3583-3592. 10.4049/jimmunol.1001535

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The β-herpesvirus CMV induces a substantial and progressive expansion of virus-specific memory CD8 T cells, which protect the host against viral reactivation from latency. In this paper, we report that this expansion, or “inflation,” of memory T cells is amplified dramatically during mouse CMV infection of IL-10 knockout (IL-10−/−) mice. T cells from IL-10−/− mice were oligoclonal, exhibited a highly activated phenotype, expressed antiviral cytokines, and degranulated in response to cognate Ag encounter ex vivo. Moreover, latent viral load was reduced in IL-10−/− mice. Importantly, these results were recapitulated by IL-10R blockade during chronic/latent infection of wild-type mice. These data demonstrate that regulatory immune mechanisms can influence CMV-specific T cell memory and suggest a possible rationale for the acquisition of functional IL-10 orthologs by herpesviruses.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: Q Science > QR Microbiology > QR180 Immunology
Q Science > QR Microbiology > QR355 Virology
Publisher: American Association of Immunologists
ISSN: 0022-1767
Funders: Wellcome Trust, Medical Research Council
Last Modified: 07 Dec 2022 07:28

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