Modulation of CD59 expression by restrictive silencer factor-derived peptides in cancer immunotherapy for neuroblastoma [RETRACTED]

Donev, Rossen Mintchev, Gray, Lisa Clare, Baalasubramanian, Sivasankar, Hughes, Timothy Richard ORCID: https://orcid.org/0000-0003-2348-3490, Van Den Berg, Carmen Wilma and Morgan, Bryan Paul ORCID: https://orcid.org/0000-0003-4075-7676 2008. Modulation of CD59 expression by restrictive silencer factor-derived peptides in cancer immunotherapy for neuroblastoma [RETRACTED]. Cancer Research 68 (14) , pp. 5979-5987. 10.1158/0008-5472.CAN-07-6828

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Abstract

Tumor cells escape clearance by complement by abundantly expressing CD59 and other membrane complement regulators. Existing strategies for blocking/knocking down these regulators can contribute to tumor immunoclearance in vitro; however, there are numerous difficulties restricting their use in vivo. Here, we report a new strategy for suppression of CD59 expression in neuroblastoma using peptides that target regulators of CD59 expression. We identified the neural-restrictive silencer factor (REST) as a target for modulation of CD59 expression in neuroblastoma. We next designed plasmids that encoded peptides comprising different DNA-binding domains of REST and transfected them into neuroblastoma cell lines. These peptides suppressed CD59 expression, sensitizing neuroblastoma to complement-mediated killing triggered by anti-GD2 therapeutic monoclonal antibody. These CD59-modulating peptides might be effective therapeutic adjuvants to therapeutic monoclonal antibodies used for treatment of neuroblastoma and other cancer types sharing the same mechanism for regulation of CD59 expression.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine Schools > Psychology
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords:	CD59; complement killing; neuroblastoma; REST; therapeutic peptides
Additional Information:	This article has been retracted. Please follow the links to the journal website for more information. Notice DOI: 10.1158/0008-5472.CAN-13-2936
Publisher:	American Association for Cancer Research
ISSN:	0008-5472
Last Modified:	06 Nov 2022 14:35
URI:	https://orca.cardiff.ac.uk/id/eprint/29881

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