NF-κB as a prognostic marker and therapeutic target in chronic lymphocytic leukemia

Pepper, Christopher John, Hewamana, Saman, Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499 and Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621 2009. NF-κB as a prognostic marker and therapeutic target in chronic lymphocytic leukemia. Future Oncology 5 (7) , pp. 1027-1037. 10.2217/fon.09.72

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Abstract

Chronic lymphocytic leukemia is the most common adult leukemia and is currently incurable with conventional chemotherapeutic agents. Over the last few years, significant discoveries have been made regarding the biology that underpins this disease. These new insights have allowed us to develop more rational prognostic tools and identify promising novel therapeutic targets. In this review, we highlight the importance of both constitutive and inducible DNA binding of the transcription factor NF-κB in chronic lymphocytic leukemia. We describe the current knowledge regarding the activity and function of specific NF-κB subunits in this disease, and discuss the complex mechanisms that regulate NF-κB activation in vivo. In addition, we provide compelling evidence for the utility of the NF-κB subunit, Rel A, as a prognostic marker and as a therapeutic target in this disease, and we also describe how this protein may contribute to the drug resistance commonly encountered with this condition.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher:	Future Medicine
ISSN:	1479-6694
Last Modified:	07 Dec 2022 07:35
URI:	https://orca.cardiff.ac.uk/id/eprint/30144

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