The biomechanics of amnion rupture: An X-Ray diffraction study

Connon, Che J., Nakamura, T., Hopkinson, A., Quantock, Andrew James ORCID: https://orcid.org/0000-0002-2484-3120, Yagi, N., Doutch, James J. and Meek, Keith Michael Andrew ORCID: https://orcid.org/0000-0002-9948-7538 2007. The biomechanics of amnion rupture: An X-Ray diffraction study. PLoS ONE 2 (11) , e1147. 10.1371/journal.pone.0001147

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Abstract

Pre-term birth is the leading cause of perinatal and neonatal mortality, 40% of which are attributed to the pre-term premature rupture of amnion. Rupture of amnion is thought to be associated with a corresponding decrease in the extracellular collagen content and/or increase in collagenase activity. However, there is very little information concerning the detailed organisation of fibrillar collagen in amnion and how this might influence rupture. Here we identify a loss of lattice like arrangement in collagen organisation from areas near to the rupture site, and present a 9% increase in fibril spacing and a 50% decrease in fibrillar organisation using quantitative measurements gained by transmission electron microscopy and the novel application of synchrotron X-ray diffraction. These data provide an accurate insight into the biomechanical process of amnion rupture and highlight X-ray diffraction as a new and powerful tool in our understanding of this process.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Physics and Astronomy Optometry and Vision Sciences
Subjects:	R Medicine > RE Ophthalmology
Publisher:	Public Library of Science
ISSN:	1932-6203
Date of First Compliant Deposit:	30 March 2016
Last Modified:	26 May 2023 12:38
URI:	https://orca.cardiff.ac.uk/id/eprint/33433

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