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Epstein-Barr virus regulates STAT1 through latent membrane protein 1

Richardson, Ciaran Joseph, Fielding, Ceri ORCID:, Rowe, Martin and Brennan, Paul ORCID: 2003. Epstein-Barr virus regulates STAT1 through latent membrane protein 1. Journal of Virology 77 (7) , pp. 4439-4443. 10.1128/JVI.77.7.4439-4443.2003

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This study shows a mechanism for the increase of signal transducer and activator of transcription 1 (STAT1) in Epstein-Barr virus-immortalized cells. Latent membrane protein 1 (LMP-1) expression was sufficient to induce STAT1 expression, DNA binding, and transcriptional activity. LMP-1-expressing cells can induce an increase in STAT1 expression in LMP-negative cells in the same culture, suggesting an indirect regulation of STAT1 expression. The increase in STAT1 expression is mediated by the C-terminal activating region 1 (CTAR-1) and/or CTAR-2 domains of LMP-1 and is inhibited by mutant IκB, demonstrating a role for NFκB in LMP-1-mediated STAT1 expression.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: Q Science > QR Microbiology > QR355 Virology
Publisher: American Society for Microbiology
ISSN: 0022-538X
Last Modified: 25 Oct 2022 09:05

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