Increased frequency of the k-ras G12C mutation in MYH polyposis colorectal adenomas

Jones, Sian, Lambert, S., Williams, Geraint Trevor ORCID: https://orcid.org/0000-0003-3768-9940, Best, J. M., Sampson, Julian Roy ORCID: https://orcid.org/0000-0002-2902-2348 and Cheadle, Jeremy Peter ORCID: https://orcid.org/0000-0001-9453-8458 2004. Increased frequency of the k-ras G12C mutation in MYH polyposis colorectal adenomas. British Journal of Cancer 90 (8) , pp. 1591-1593. 10.1038/sj.bjc.6601747

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Abstract

Colorectal tumours from MYH polyposis patients display an excess of somatic G : C right arrow T : A transversions in the adenomatous polyposis coli gene. Here, we identify k-ras mutations in nine out of 54 (16.7%) MYH polyposis tumours. Their presence was associated with increased dysplasia and tubulovillous morphology (P=0.005). G : C right arrow T : A transversions in k-ras were significantly more frequent in MYH polyposis adenomas than in sporadic or familial adenomatous polyposis-associated tumours (Pless than or equal to0.002), and all resulted in a glycine-to-cysteine substitution at codon 12.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	Q Science > QH Natural history > QH426 Genetics R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords:	k-ras; MYH; colorectal adenoma; G : C right arrow T : A mutations; G12C
Publisher:	Nature Publishing Group
ISSN:	0007-0920
Date of First Compliant Deposit:	30 March 2016
Last Modified:	12 Aug 2024 12:42
URI:	https://orca.cardiff.ac.uk/id/eprint/59932

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