Synthesis of substituted carbamo(dithioperoxo)thioates as potential BCA2-inhibitory anticancer agents

Cilibrasi, Vincenzo, Tsang, Kwok Ying Ingrid, Morelli, Matteo, Solfa, Francesca, Wiggins, Helen, Jones, Arwyn Tomos ORCID: https://orcid.org/0000-0003-2781-8905 and Westwell, Andrew David ORCID: https://orcid.org/0000-0002-5166-9236 2015. Synthesis of substituted carbamo(dithioperoxo)thioates as potential BCA2-inhibitory anticancer agents. Tetrahedron Letters 56 (20) , pp. 2583-2585. 10.1016/j.tetlet.2015.03.132

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Abstract

A new, simple, one-step synthetic route to carbamo(dithioperoxo)thioates from commercially available starting materials is described. The key step of this new synthetic approach involves the tetrabromomethane-promoted reaction between secondary amines, carbon disulfide and alkyl thiols under basic conditions at room temperature. New compounds from this series selected for anticancer screening showed selective sub-micromolar activity within BCA2-expressing human breast cancer cell lines.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Pharmacy
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords:	Carbamo(dithioperoxo)thioates; Tetrabromomethane; Disulfiram analogues; BCA2 inhibitors; Anticancer agents
Publisher:	Elsevier
Date of First Compliant Deposit:	30 March 2016
Date of Acceptance:	31 March 2015
Last Modified:	21 Nov 2024 00:15
URI:	https://orca.cardiff.ac.uk/id/eprint/72118

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