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Synthesis of substituted carbamo(dithioperoxo)thioates as potential BCA2-inhibitory anticancer agents

Cilibrasi, Vincenzo, Tsang, Kwok Ying Ingrid, Morelli, Matteo, Solfa, Francesca, Wiggins, Helen, Jones, Arwyn Tomos ORCID: and Westwell, Andrew David ORCID: 2015. Synthesis of substituted carbamo(dithioperoxo)thioates as potential BCA2-inhibitory anticancer agents. Tetrahedron Letters 56 (20) , pp. 2583-2585. 10.1016/j.tetlet.2015.03.132

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A new, simple, one-step synthetic route to carbamo(dithioperoxo)thioates from commercially available starting materials is described. The key step of this new synthetic approach involves the tetrabromomethane-promoted reaction between secondary amines, carbon disulfide and alkyl thiols under basic conditions at room temperature. New compounds from this series selected for anticancer screening showed selective sub-micromolar activity within BCA2-expressing human breast cancer cell lines.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords: Carbamo(dithioperoxo)thioates; Tetrabromomethane; Disulfiram analogues; BCA2 inhibitors; Anticancer agents
Publisher: Elsevier
Date of First Compliant Deposit: 30 March 2016
Date of Acceptance: 31 March 2015
Last Modified: 08 Nov 2023 13:18

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