High endothelial venules are rare in colorectal cancers but accumulate in extra-tumoral areas with disease progression

Costa Bento, Diana Filipa, Jones, Emma, Junaid, Syed, Tull, Justyna, Williams, Geraint Trefor ORCID: https://orcid.org/0000-0003-3768-9940, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Ager, Ann and Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004 2015. High endothelial venules are rare in colorectal cancers but accumulate in extra-tumoral areas with disease progression. OncoImmunology 4 (3) , pp. 653-660. 10.4161/2162402X.2014.974374

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Abstract

Prolonged patient survival after surgical resection, is associated with a higher cytotoxic and memory T cell density within colorectal cancers (CRC). High endothelial venules (HEVs) are specialized blood vessels present in secondary lymphoid organs (SLO) that allow ingress of naïve and central memory T cells from the blood. It has been proposed that HEVs in tumors might serve as a similar route of entry for lymphocytes into the tumor and result in an improved prognosis. The present study aimed to characterize HEVs and their microenvironment in resected tumors from colorectal cancer patients (n = 62). We observed HEVs in association with lymphoid aggregates in 49 out of 62 patients. However, these HEV+ lymphoid aggregates were largely at the invasive margin of the tumor and although there was an association with lymphocytes and HEVs at the invasive margin (p = 0.002) there was only a very weak association with tumor infiltrating lymphocytes. Indeed, lymphoid aggregates were associated with more advanced disease (Dukes’ stage C) and did not indicate a favorable prognosis.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords:	colorectal cancer, high endothelial venules, lymphoid aggregates/follicles, T cells, tumor infiltrating lymphocytes and tertiary lymphoid organs, A/F, aggregate/ follicle, CRC, colorectal cancer, HEV, high endothelial venule, TILs, tumor-infiltrating lymphocytes, Treg, regulatory T cell.
Publisher:	Taylor & Francis
ISSN:	2162-402X
Funders:	Wellcome Trust
Date of First Compliant Deposit:	30 March 2016
Date of Acceptance:	3 October 2014
Last Modified:	07 May 2023 18:47
URI:	https://orca.cardiff.ac.uk/id/eprint/72813

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