Early innate responses to pathogens: pattern recognition by unconventional human T-cells

Liuzzi, Anna Rita, McLaren, James Edward ORCID: https://orcid.org/0000-0002-7021-5934, Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Eberl, Matthias ORCID: https://orcid.org/0000-0002-9390-5348 2015. Early innate responses to pathogens: pattern recognition by unconventional human T-cells. Current Opinion in Immunology 36 , pp. 31-37. 10.1016/j.coi.2015.06.002

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Abstract

Although typically viewed as a feature of innate immune responses, microbial pattern recognition is increasingly acknowledged as a function of particular cells nominally categorized within the adaptive immune system. Groundbreaking research over the past three years has shown how unconventional human T-cells carrying invariant or semi-invariant TCRs that are not restricted by classical MHC molecules sense microbial compounds via entirely novel antigen presenting pathways. This review will focus on the innate-like recognition of non-self metabolites by Vγ9/Vδ2 T-cells, mucosal-associated invariant T (MAIT) cells and germline-encoded mycolyl-reactive (GEM) T-cells, with an emphasis on early immune responses in acute infection.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine Research Institutes & Centres > Systems Immunity Research Institute (SIURI)
Subjects:	Q Science > QR Microbiology > QR180 Immunology
Additional Information:	Available online 13 July 2015
Publisher:	Elsevier
ISSN:	0952-7915
Date of First Compliant Deposit:	30 March 2016
Last Modified:	21 Nov 2024 13:26
URI:	https://orca.cardiff.ac.uk/id/eprint/74724

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