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Early innate responses to pathogens: pattern recognition by unconventional human T-cells

Liuzzi, Anna Rita, McLaren, James Edward ORCID:, Price, David ORCID: and Eberl, Matthias ORCID: 2015. Early innate responses to pathogens: pattern recognition by unconventional human T-cells. Current Opinion in Immunology 36 , pp. 31-37. 10.1016/j.coi.2015.06.002

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Although typically viewed as a feature of innate immune responses, microbial pattern recognition is increasingly acknowledged as a function of particular cells nominally categorized within the adaptive immune system. Groundbreaking research over the past three years has shown how unconventional human T-cells carrying invariant or semi-invariant TCRs that are not restricted by classical MHC molecules sense microbial compounds via entirely novel antigen presenting pathways. This review will focus on the innate-like recognition of non-self metabolites by Vγ9/Vδ2 T-cells, mucosal-associated invariant T (MAIT) cells and germline-encoded mycolyl-reactive (GEM) T-cells, with an emphasis on early immune responses in acute infection.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: Q Science > QR Microbiology > QR180 Immunology
Additional Information: Available online 13 July 2015
Publisher: Elsevier
ISSN: 0952-7915
Date of First Compliant Deposit: 30 March 2016
Last Modified: 11 Oct 2023 17:11

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