Chemoselective N-deacetylation of protected nucleosides and nucleotides promoted by the Schwartz's reagent

Ferrari, Valentina ORCID: https://orcid.org/0000-0003-1895-8906, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101 2015. Chemoselective N-deacetylation of protected nucleosides and nucleotides promoted by the Schwartz's reagent. Nucleosides, Nucleotides & Nucleic Acids 34 (11) , pp. 799-814. 10.1080/15257770.2015.1075552

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Abstract

Protection and deprotection strategies involving the N-acetyl group are widely utilized in nucleoside and nucleotide chemistry. Herein, we present a mild and selective N-deacetylation methodology, applicable to purine and pyrimidine nucleosides, by means of Schwartz's reagent, compatible with most of the common protecting groups used in nucleoside chemistry.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Additional Information:	Published online: 22 Oct 2015 This is an Open Access article. Non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly attributed, cited, and is not altered, transformed, or built upon in any way, is permitted
Publisher:	Taylor & Francis
ISSN:	1525-7770
Date of First Compliant Deposit:	30 March 2016
Date of Acceptance:	20 July 2015
Last Modified:	06 May 2023 18:09
URI:	https://orca.cardiff.ac.uk/id/eprint/77077

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