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Number of items: 34.

Tisnerat, Camille, Di Ciano, Samuele, Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101 and Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910 2025. Microwave-accelerated synthesis of novel triphosphate nucleoside prodrugs: Expanding the therapeutic arsenal of anticancer agents. Organic Letters 27 (1) , pp. 322-327. 10.1021/acs.orglett.4c04379
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Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Morozzi, Chiara, James, Edward, Renno, Giacomo, Cardano, Francesca and Fin, Andrea 2024. Fingolimod phosphoramidate prodrugs: Synthesis, photophysical characterisation and lipid bilayer interaction of fluorescent tagged Prodrug. Journal of Molecular Structure 1312 (2) , 138614. 10.1016/j.molstruc.2024.138614
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Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, di Ciano, Samule and Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101 2024. Design, synthesis and biological evaluation of aryloxy thiophosphoramidate triesters of anticancer nucleoside analogues. Bioorganic and Medicinal Chemistry 103 , 117696. 10.1016/j.bmc.2024.117696
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Douglas, EdwardJ. A., Marshall, Brandon, Alghamadi, Arwa, Joseph, Erin A., Duggan, Seána, Vittorio, Serena, De Luca, Laura, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910 and Laabei, Maisem 2023. Improved antibacterial activity of 1,3,4-oxadiazole-based compounds that restrict Staphylococcus aureus growth independent of LtaS function. ACS Infectious Diseases 9 (11) , pp. 2141-2159. 10.1021/acsinfecdis.3c00250
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Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Morozzi, Chiara, Novelli, Giulia, Giannantonio, Daniele, Duggan, Katrina, Vittorio, Serena, Fallis, Ian A. ORCID: https://orcid.org/0000-0001-7361-0182, De Luca, Laura and Williams, David ORCID: https://orcid.org/0000-0002-7351-5131 2023. Synthesis, molecular docking and antibacterial activity of an oxadiazole-based lipoteichoic acid inhibitor and its metabolites. Journal of Molecular Structure 1278 , 134977. 10.1016/j.molstruc.2023.134977
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Cook, Sophie R., Kirkham, Emily D., Best, Hannah, Waller-Evans, Helen ORCID: https://orcid.org/0000-0003-4133-6064, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101 and Lloyd-Evans, Emyr ORCID: https://orcid.org/0000-0002-3626-1611 2023. Investigating lysosomal and cellular phenotypes of the lysosomal disorder cystinosis. Presented at: 19th Annual WORLDSymposium™ 2023, Orlando, Florida, 21-26 February 2023. Molecular Genetics and Metabolism. , vol.138 (2) Elsevier, p. 28. 10.1016/j.ymgme.2022.107061

Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Ferrari, Valentina ORCID: https://orcid.org/0000-0003-1895-8906, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Ghazaly, Essam and Pepper, Chris 2022. Synthesis and characterization of nuc-7738, an aryloxy phosphoramidate of 3?-deoxyadenosine, as a potential anticancer agent. Journal of Medicinal Chemistry 65 (23) , pp. 15789-15804. 10.1021/acs.jmedchem.2c01348
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Schwenzer, Hagen, De Zan, Erica, Elshani, Mustafa, van Stiphout, Ruud, Kudsy, Mary, Morris, Josephine, Ferrari, Valentina ORCID: https://orcid.org/0000-0003-1895-8906, Um, In Hwa, Chettle, James, Kazmi, Farasat, Campo, Leticia, Easton, Alistair, Nijman, Sebastian, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Symeonides, Stefan, Plummer, Ruth, Harrison, David J., Bond, Gareth and Blagden, Sarah P. 2021. The novel nucleoside analogue ProTide NUC-7738 overcomes cancer resistance mechanisms in vitro and in a first-in-human Phase 1 clinical trial. Clinical Cancer Research 27 (23) , pp. 6500-6513. 10.1158/1078-0432.CCR-21-1652
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Slusarczyk, Magdalena ORCID: https://orcid.org/0000-0002-4707-7190, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Ghazaly, Essam, Kariuki, Benson M. ORCID: https://orcid.org/0000-0002-8658-3897, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Pepper, Chris 2021. Single diastereomers of the clinical anticancer ProTide agents NUC-1031 and NUC-3373 preferentially target cancer stem cells in vitro. Journal of Medicinal Chemistry 64 (12) , pp. 8179-8193. 10.1021/acs.jmedchem.0c02194
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NuCana PLC 2021. Phosphoramidate nucleoside derivatives as anticancer agents. WO2017207986A1; US20210130387A1. [Patent].

Vanden Avond, Mark A., Meng, Hui, Beatka, Margaret J., Helbling, Daniel C., Prom, Mariah J., Sutton, Jessica L., Slick, Rebecca A., Dimmock, David P., Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Pileggi, Elisa, Crutcher, Patrick, Thomas, Stephen and Lawlor, Michael W. 2021. The nucleotide prodrug CERC‐913 improves mtDNA content in primary hepatocytes from DGUOK‐deficient rats. Journal of Inherited Metabolic Disease 44 (2) , pp. 492-501. 10.1002/jimd.12354
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Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910 and Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101 2021. An overview of ProTide technology and its implications to drug discovery. Expert Opinion on Drug Discovery 16 (10) , 1149--1161. 10.1080/17460441.2021.1922385
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Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Pileggi, Elisa, Richards, Jennifer, Wootton, Mandy, Van Leemputte, Thijs, Persoons, Leentje, De Coster, David, Villanueva, Xabier, Daelemans, Dirk, Steenackers, Hans, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910 2020. Drug repurposing: phosphate prodrugs of anticancer and antiviral FDA-approved nucleosides as novel antimicrobials. Journal of Antimicrobial Chemotherapy 75 (10) , pp. 2864-2878. 10.1093/jac/dkaa268
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Morozzi, Chiara, Sedláková, Jana, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Avigliano, Marialuce, Carbajo, Rosangela, Sandoval, Lucia, Valles-Ayoub, Yadira, Crutcher, Patrick, Thomas, Stephen and Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101 2019. Targeting GNE myopathy: A dual prodrug approach for the delivery of N-acetylmannosamine 6-phosphate. Journal of Medicinal Chemistry 62 (17) , pp. 8178-8193. 10.1021/acs.jmedchem.9b00833
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Slusarczyk, Magdalena ORCID: https://orcid.org/0000-0002-4707-7190, Ferrari, Valentina ORCID: https://orcid.org/0000-0003-1895-8906, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Gonczy, Blanka, Balzarini, Jan and McGuigan, Christopher 2018. Symmetrical diamidates as a class of phosphate prodrugs to deliver the 5'-monophosphate form of anticancer nucleoside analogues. ChemMedChem 13 (21) , pp. 2305-2316. 10.1002/cmdc.201800504
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Pileggi, Elisa, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910 and Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101 2018. Preparation of pyrimidine alkenyl acyclic nucleoside phosphonoamidates. Current Protocols in Nucleic Acid Chemistry 74 (13-14) , e56. 10.1002/cpnc.56
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Pileggi, Elisa, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Andrei, Graciela, Schols, Dominique, Snoeck, Robert and Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101 2018. Expedient synthesis and biological evaluation of alkenyl acyclic nucleoside phosphonate prodrugs. Bioorganic and Medicinal Chemistry 26 (12) , pp. 3596-3609. 10.1016/j.bmc.2018.05.034
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Slusarczyk, Magdalena ORCID: https://orcid.org/0000-0002-4707-7190, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910 and Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101 2018. Phosphoramidates and phosphonamidates (ProTides) with antiviral activity. Antiviral Chemistry and Chemotherapy 26 , pp. 1-31. 10.1177/2040206618775243
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NuCana Biomed Ltd 2017. Adenosine derivatives for use in the treatment of cancer. WO2017207989A1. [Patent].

Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, De Biasi, Roberto, Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Slusarczyk, Magdalena ORCID: https://orcid.org/0000-0002-4707-7190 and McGuigan, Christopher 2017. Synthetic approaches for the preparation of phosphoramidate prodrugs of 2’-deoxypseudoisocytidine. ChemistryOpen 6 (3) , pp. 424-436. 10.1002/open.201700019
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Marinozzi, Maura, Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101 and Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910 2016. λ5-Phosphorus-Containing α-Diazo Compounds (PCDCs): a valuable tool for accessing phosphorus-functionalized molecules. Chemical Reviews 116 (22) , pp. 13991-14055. 10.1021/acs.chemrev.6b00373
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Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Ferrari, Valentina and Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101 2016. Nucleosided derived antibiotics to fight microbial drug resistance: New utilities for an established class of drugs? Journal of Medicinal Chemistry 59 (23) , pp. 10343-10382. 10.1021/acs.jmedchem.6b00325
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McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Slusarczyk, Magdalena ORCID: https://orcid.org/0000-0002-4707-7190, Ferrari, Valentina ORCID: https://orcid.org/0000-0003-1895-8906, Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Meneghesso, Silvia, Derudas, Marco, Farleigh, Laura, Zanetta, Paola and Bugert, Joachim ORCID: https://orcid.org/0000-0002-0556-3211 2016. Anti-flavivirus activity of different tritylated pyrimidine and purine nucleoside analogues. ChemistryOpen 5 (3) , pp. 227-235. 10.1002/open.201500216
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Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910 2015. Symmetrical diamidate prodrugs of nucleotide analogues for drug delivery. Current Protocols in Nucleic Acid Chemistry, Wiley-Blackwell, 60:15.6.1-15.6.10. (10.1002/0471142700.nc1506s60)
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NuCana PLC 2015. Gemcitabine Prodrugs. WO 2015/198058; GB51857. [Patent].

Ferrari, Valentina ORCID: https://orcid.org/0000-0003-1895-8906, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101 2015. Chemoselective N-deacetylation of protected nucleosides and nucleotides promoted by the Schwartz's reagent. Nucleosides, Nucleotides & Nucleic Acids 34 (11) , pp. 799-814. 10.1080/15257770.2015.1075552
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Ferrari, Valentina ORCID: https://orcid.org/0000-0003-1895-8906 and Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910 2015. Nucleoside analogs and tuberculosis: new weapons against an old enemy. Future Medicinal Chemistry 7 (3) , pp. 291-314. 10.4155/fmc.14.166
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McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Derudas, Marco, Gonczy, Blanka, Hinsinger, Karen, Kandil, Sahar ORCID: https://orcid.org/0000-0003-1806-9623, Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Snoeck, Robert, Andrei, Graciela, Balzarini, Jan, McHugh, Timothy D., Maitra, Arundhati, Akorli, Ernest, Evangelopoulos, Dimitrios and Bhakta, Sanjib 2014. ProTides of N-(3-(5-(2'-deoxyuridine))prop-2-ynyl)octanamide as potential anti-tubercular and anti-viral agents. Bioorganic and Medicinal Chemistry 22 (9) , pp. 2816-2824. 10.1016/j.bmc.2014.02.056
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Magdalena Slusarczyk 2014. Prodrug. IN 2014MU02050. [Patent].

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Bourdin, Claire, Derudas, Marco, Hamon, Nadege, Hinsinger, Karen, Kandil, Sahar ORCID: https://orcid.org/0000-0003-1806-9623, Madela, Karolina, Meneghesso, Silvia, Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Slusarczyk, Magdalena ORCID: https://orcid.org/0000-0002-4707-7190, Chamberlain, Stanley, Kolykhalov, Alexander, Vernachio, John, Vanpouille, Christophe, Introini, Andrea, Margolis, Leonid and Balzarini, Jan 2013. Design, synthesis and biological evaluation of phosphorodiamidate prodrugs of antiviral and anticancer nucleosides. European Journal of Medicinal Chemistry 70 , pp. 326-340. 10.1016/j.ejmech.2013.09.047
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Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Bibbo, Rita, Rat, Stephanie, Roberts, Helen Christina, Hughes, Clare Elizabeth ORCID: https://orcid.org/0000-0003-4726-5877, Caterson, Bruce ORCID: https://orcid.org/0000-0001-6016-0661, Alcaraz, María José, Gibert, Anna Torrent, Verson, Carlos Raul Alaez and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2012. Novel phosphoramidate prodrugs of N-Acetyl-(d)-Glucosamine with antidegenerative activity on bovine and human cartilage explants. Journal of Medicinal Chemistry 55 (10) , pp. 4629-4639. 10.1021/jm300074y

Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910 and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2011. Medicinal chemistry of nucleoside phosphonate prodrugs for antiviral therapy. Antiviral Chemistry and Chemotherapy 22 (5) , pp. 181-203. 10.3851/IMP2012
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Morgan, Alwena Haf, Hammond, Victoria Jayne, Morgan, Lloyd, Thomas, Christopher P. ORCID: https://orcid.org/0000-0001-5840-8613, Tallman, Keri A., Garcia-Diaz, Yoel Ruslan, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Porter, Ned A., Murphy, Robert C. and O'Donnell, Valerie Bridget ORCID: https://orcid.org/0000-0003-4089-8460 2010. Quantitative assays for esterified oxylipins generated by immune cells. Nature Protocols 5 (12) , pp. 1919-1931. 10.1038/nprot.2010.162

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Bibbo, Rita, Roberts, Helen Christina, Hughes, Clare Elizabeth ORCID: https://orcid.org/0000-0003-4726-5877, Caterson, Bruce ORCID: https://orcid.org/0000-0001-6016-0661, Gibert, Ana Torrent and Verson, Carlos Raul Alaez 2008. Phosphate prodrugs derived from N-acetylglucosamine have enhanced chondroprotective activity in explant cultures and represent a new lead in antiosteoarthritis drug discovery. Journal of Medicinal Chemistry 51 (18) , pp. 5807-5812. 10.1021/jm800594c

This list was generated on Mon Oct 27 10:48:25 2025 GMT.


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