Acute kidney injury: a paradigm for miRNA regulation of the cell cycle

Khalid, Usman, Bowen, Timothy ORCID: https://orcid.org/0000-0001-6050-0435, Fraser, Donald ORCID: https://orcid.org/0000-0003-0102-9342 and Jenkins, Robert ORCID: https://orcid.org/0000-0001-8500-9044 2014. Acute kidney injury: a paradigm for miRNA regulation of the cell cycle. Biochemical Society Transactions 42 (4) , pp. 1219-1223. 10.1042/BST20140093

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Abstract

miRNAs are small, endogenous, post-transcriptional regulators of gene expression. AKI (acute kidney injury) of various aetiologies, including trauma, sepsis and IRI (ischaemia/reperfusion injury) in the context of kidney transplantation, or drug toxicity, has a high morbidity and mortality rate and presents a significant burden to health services worldwide. AKI primarily affects the renal cortex, in particular PTCs (proximal tubular epithelial cells). Current research demonstrates causality between G2/M cell cycle arrest of PTCs and AKI. Recent findings from our laboratory and others presented in this review implicate miRNA regulation of the cell cycle in the pathology of AKI.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine Research Institutes & Centres > Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Portland Press
ISSN:	0300-5127
Last Modified:	17 Nov 2022 07:50
URI:	https://orca.cardiff.ac.uk/id/eprint/79250

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