Sewell, Andrew K.  ORCID: https://orcid.org/0000-0003-3194-3135, Harcourt, Gillian C., Goulder, Philip J. R., Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Phillips, Rodney E.
1997.
Antagonism of cytotoxic T lymphocyte-mediated lysis by natural HIV-1 altered peptide ligands requires simultaneous presentation of agonist and antagonist peptides.
European Journal of Immunology
27
(9)
, pp. 2323-2329.
10.1002/eji.1830270929
|
Abstract
Mutations in human immunodeficiency virus (HIV) cluster in cytotoxic T lymphocyte (CTL) epitopes (Phillips, R. E. et al., Nature 1991. 354: 453) and are subject to immune-mediated positive selection (Price, D. A. et al., Proc. Natl. Acad. Sci. USA 1997. 94: 1890). We studied the effects of naturally occurring mutations in the HIV-1 p17 Gag HLA A2 restricted epitope SLYNTVATL on recognition by anti-HIV CTL. Most of these naturally occurring mutants escaped killing by one CTL line and the majority acted as CTL antagonists. We also investigated whether CTL exposed to a strict antagonist peptide restricted by HLA A2 were unresponsive when exposed to targets presenting the wild-type sequence. The results show that antagonism of anti-HIV CTL killing requires the simultaneous presence of agonist and antagonist peptide. We found no evidence that CTL exposed to an antagonist received a functionally negative signal since these CTL retained an unimpaired capacity to lyse targets bearing wild-type peptide.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine |
| Subjects: | Q Science > QR Microbiology > QR180 Immunology |
| Publisher: | John Wiley & Sons |
| ISSN: | 0014-2980 |
| Date of First Compliant Deposit: | 16 June 2016 |
| Date of Acceptance: | 17 June 1997 |
| Last Modified: | 01 Nov 2022 10:32 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/91926 |
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