The role of IL-22 in viral infections: paradigms and paradoxes

Gimeno Brias, Silvia, Stack, Gabrielle, Stacey, Maria A., Redwood, Alec J. and Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 2016. The role of IL-22 in viral infections: paradigms and paradoxes. Frontiers in Immunology 7 , 00211. 10.3389/fimmu.2016.00211

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Abstract

Interleukin-22 (IL-22) is a member of the IL-10 family of cytokines. Hematopoietic cells express IL-22, and this cytokine signals through the heterodimeric IL-22 receptor expressed by non-hematopoietic cells. A growing body of evidence points toward a role for IL-22 in a diverse array of biological functions ranging from cellular proliferation, tissue protection and regeneration, and inflammation. In recent years, the role that IL-22 plays in antiviral immune responses has been examined in a number of infection models. Herein, we assess our current understanding of how IL-22 determines the outcome of viral infections and define common mechanisms that are evident from, sometimes paradoxical, findings derived from these studies. Finally, we discuss the potential therapeutic utility of IL-22 manipulation in the treatment and prevention of viral infections and associated pathologies.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	Q Science > QR Microbiology > QR180 Immunology
Publisher:	Frontiers Research Foundation
ISSN:	1664-3224
Funders:	Wellcome Trust
Date of First Compliant Deposit:	20 June 2016
Date of Acceptance:	17 May 2016
Last Modified:	05 May 2023 20:56
URI:	https://orca.cardiff.ac.uk/id/eprint/92017

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