Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders

Lo, Min-Tzu, Hinds, David A., Tung, Joyce Y., Franz, Carol, Fan, Chun-Chieh, Wang, Yunpeng, Smeland, Olav B., Schork, Andrew, Holland, Dominic, Kauppi, Karolina, Sanyal, Nilotpal, Escott-Price, Valentina ORCID: https://orcid.org/0000-0003-1784-5483, Smith, Daniel J., O'Donovan, Michael C. ORCID: https://orcid.org/0000-0001-7073-2379, Stefansson, Hreinn, Bjornsdottir, Gyda, Thorgeirsson, Thorgeir E., Stefansson, Kari, McEvoy, Linda K., Dale, Anders M., Andreassen, Ole A. and Chen, Chi-Hua 2017. Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders. Nature Genetics 49 , pp. 152-156. 10.1038/ng.3736

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Abstract

Personality is influenced by genetic and environmental factors1 and associated with mental health. However, the underlying genetic determinants are largely unknown. We identified six genetic loci, including five novel loci2, 3, significantly associated with personality traits in a meta-analysis of genome-wide association studies (N = 123,132–260,861). Of these genome-wide significant loci, extraversion was associated with variants in WSCD2 and near PCDH15, and neuroticism with variants on chromosome 8p23.1 and in L3MBTL2. We performed a principal component analysis to extract major dimensions underlying genetic variations among five personality traits and six psychiatric disorders (N = 5,422–18,759). The first genetic dimension separated personality traits and psychiatric disorders, except that neuroticism and openness to experience were clustered with the disorders. High genetic correlations were found between extraversion and attention-deficit–hyperactivity disorder (ADHD) and between openness and schizophrenia and bipolar disorder. The second genetic dimension was closely aligned with extraversion–introversion and grouped neuroticism with internalizing psychopathology (e.g., depression or anxiety).

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	Behavioural genetics Genome-wide association studies
Additional Information:	Title changed between acceptance and publication
Publisher:	Nature
ISSN:	1061-4036
Date of First Compliant Deposit:	21 December 2016
Date of Acceptance:	2 November 2016
Last Modified:	06 Nov 2023 19:25
URI:	https://orca.cardiff.ac.uk/id/eprint/97008

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