Telomere length is a critical determinant for survival in multiple myeloma

Hyatt, Sam, Robinson, Rhiannon, Hepple, Nicole, Grimstead, Julia, Hills, Robert Kerrin ORCID: https://orcid.org/0000-0003-0166-0062, Fegan, Christopher ORCID: https://orcid.org/0000-0001-9685-0621, Jackson, Graham, allan, James, Pratt, Guy, Pepper, Christopher John and Baird, Duncan Martin ORCID: https://orcid.org/0000-0001-8408-5467 2017. Telomere length is a critical determinant for survival in multiple myeloma. British Journal of Haematology 178 (1) , pp. 94-98. 10.1111/bjh.14643

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Abstract

The variable clinical outcomes of Multiple Myeloma (MM) patients are incompletely defined by current prognostication tools. We examined the clinical utility of high-resolution telomere length analysis as a prognostic marker in MM. Cohort stratification, using a previously determined length threshold for telomere dysfunction, revealed that patients with short telomeres had a significantly shorter overall survival (P < 0·0001; HR = 3·4). Multivariate modelling using forward selection identified International Staging System (ISS) stage as the most important prognostic factor, followed by age and telomere length. Importantly, each ISS prognostic subset could be further risk-stratified according to telomere length, supporting the inclusion of this parameter as a refinement of the ISS.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords:	multiple myeloma; prognosis; telomere; genome instability
Publisher:	Wiley-Blackwell
ISSN:	0007-1048
Funders:	Cancer Research UK, Bloodwise, Leukaemia Research Appeal for Wales
Date of First Compliant Deposit:	4 January 2017
Date of Acceptance:	19 December 2016
Last Modified:	16 May 2023 21:35
URI:	https://orca.cardiff.ac.uk/id/eprint/97177

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