Nucleosided derived antibiotics to fight microbial drug resistance: New utilities for an established class of drugs?

Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Ferrari, Valentina and Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101 2016. Nucleosided derived antibiotics to fight microbial drug resistance: New utilities for an established class of drugs? Journal of Medicinal Chemistry 59 (23) , pp. 10343-10382. 10.1021/acs.jmedchem.6b00325

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Abstract

Novel antibiotics are urgently needed to combat the rise of infections due to drug-resistant microorganisms. Numerous natural nucleosides and their synthetically modified analogues have been reported to have moderate to good antibiotic activity against different bacterial and fungal strains. Nucleoside-based compounds target several crucial processes of bacterial and fungal cells such as nucleoside metabolism and cell wall, nucleic acid, and protein biosynthesis. Nucleoside analogues have also been shown to target many other bacterial and fungal cellular processes although these are not well characterized and may therefore represent opportunities to discover new drugs with unique mechanisms of action. In this Perspective, we demonstrate that nucleoside analogues, cornerstones of anticancer and antiviral treatments, also have great potential to be repurposed as antibiotics so that an old drug can learn new tricks.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Subjects:	R Medicine > RS Pharmacy and materia medica
Publisher:	American Chemical Society
ISSN:	0022-2623
Date of First Compliant Deposit:	6 February 2017
Date of Acceptance:	8 September 2016
Last Modified:	30 Nov 2024 14:00
URI:	https://orca.cardiff.ac.uk/id/eprint/98089

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