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Juhas, Mario, Widlake, Emma, Teo, Jeanette, Huseby, Douglas L, Tyrrell, Jonathan M ORCID: https://orcid.org/0000-0001-8565-2590, Polikanov, Yury S, Ercan, Onur, Petersson, Anna, Cao, Sha, Aboklaish, Ali F, Rominski, Anna, Crich, David, Böttger, Erik C, Walsh, Timothy R ORCID: https://orcid.org/0000-0003-4315-4096, Hughes, Diarmaid and Hobbie, Sven N
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The polymyxin derivative NAB739 is synergistic with several antibiotics against polymyxin-resistant strains of Escherichia coli, Klebsiella pneumoniae and Acinetobacter baumannii.
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Novel partners with colistin to increase its in vivo therapeutic effectiveness and prevent the occurrence of colistin resistance in NDM- and MCR-co-producing Escherichia coli in a murine infection model.
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Heavy metal resistance genes are associated with blaNDM-1 and blaCTX-M-15-Enterobacteriaceae.
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Clinical validation of sensitest colistin, a broth microdilution-based method to evaluate colistin MICs.
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Structure-activity studies on polymyxin derivatives carrying three positive charges only reveal a new class of compounds with strong antibacterial activity.
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Comprehensive resistome analysis reveals the prevalence of NDM and MCR-1 in Chinese poultry production.
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