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Number of items: 43.

Williams, Alan J., Thomas, N. Lowri and George, Christopher H. 2018. The ryanodine receptor: advances in structure and organization. Current Opinion in Physiology 1 , pp. 1-6. 10.1016/j.cophys.2017.10.003
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Dhanjal, Tarvinder S., Lellouche, Nicolas, Von Ruhland, Christopher, Abehsira, Guillaume, Edwards, David H., Dubois-Randé, Jean-Luc, Moschonas, Konstantinos, Teiger, Emmanuel, Williams, Alan J. and George, Christopher H. 2017. Massive accumulation of myofibroblasts in the critical isthmus is associated with ventricular tachycardia inducibility in post-infarct swine heart. Journal of the American College of Cardiology: Clinical Electrophysiology 3 (7) , pp. 703-714. 10.1016/j.jacep.2016.11.010
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Handhle, Ahmed, Ormonde, Chloe E., Thomas, N. Lowri ORCID: https://orcid.org/0000-0001-8822-8576, Bralesford, Catherine, Williams, Alan John, Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547 and Zissimopoulos, Spyros 2016. Calsequestrin interacts directly with the cardiac ryanodine receptor luminal domain. Journal of Cell Science 129 (21) , pp. 3983-3988. 10.1242/jcs.191643
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Mukherjee, Saptarshi, Thomas, N. Lowri ORCID: https://orcid.org/0000-0001-8822-8576 and Williams, Alan John 2016. Unambiguous observation of blocked states reveals altered, blocker-induced, cardiac ryanodine receptor gating. Scientific Reports 6 , 34452. 10.1038/srep34452
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Bannister, Mark L., Alvarez-Laviada, Anita, Thomas, N. Lowri ORCID: https://orcid.org/0000-0001-8822-8576, Mason, Sammy A., Coleman, Sharon, du Plessis, Christo L., Moran, Abbygail T., Neill-Hall, David, Osman, Hasnah, Bagley, Mark C., MacLeod, Kenneth T., George, Christopher H. and Williams, Alan J. 2016. Effect of flecainide derivatives on sarcoplasmic reticulum calcium release suggests a lack of direct action on the cardiac ryanodine receptor. British Journal of Pharmacology 173 (15) , pp. 2446-2459. 10.1111/bph.13521
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Wei, Risheng, Wang, Xue, Zhang, Yan, Mukherjee, Saptarshi, Zhang, Lei, Chen, Qiang, Huang, Xinrui, Jing, Shan, Liu, Congcong, Li, Shuang, Wang, Guangyu, Xu, Yaofang, Zhu, Sujie, Williams, Alan John, Sun, Fei and Yin, Chang-Cheng 2016. Structural insights into Ca2+-activated long-range allosteric channel gating of RyR1. Cell Research 26 (9) , pp. 977-994. 10.1038/cr.2016.99
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Dhanjal, Tarvinder, Lellouche, Nicolas, Von Ruhland, Christopher John, Edwards, David Hughes, George, Christopher and Williams, Alan 2016. LAVA sites are histologically closely related to critical isthmus sites in post-infarct ventricular tachycardia. Presented at: Heart Rhythm 2016 - 37th Annual Scientific Sessions, San Francisco, CA, USA, 4 May 2016.
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Jones, Aled, Edwards, David Hughes and Williams, Alan John 2016. Characterisation of cardiomyocytes derived from human induced pluripotent stem cells as monolayers [Poster Abstract]. The Lancet 387 (S1) , S56. 10.1016/S0140-6736(16)00443-8

Jones, Aled R., Edwards, David Hughes, Cummins, Michael J., Williams, Alan John and George, Christopher H. 2016. A systematized approach to investigate Ca2+ synchronization in iPSC-derived cardiomyocyte networks. Biophysical Journal 110 (3) , 435a. 10.1016/j.bpj.2015.11.2346

Jones, Aled, Edwards, David Hughes, Cummins, Michael J., Williams, Alan John and George, Christopher H. 2016. A systemized approach to investigate Ca2+ synchronization in clusters of human induced pluripotent stem-cell derived cardiomyocytes. Frontiers in Cell and Developmental Biology 3 , 89. 10.3389/fcell.2015.00089
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Dhanjal, Tarvinder, Lellouche, Nicolas, Von Ruhland, Christopher, Edwards, David, George, Christopher and Williams, Alan 2016. Increased myofibroblast densities are specific to critical isthmus sites in post-infarct re-entrant ventricular tachycardia. Presented at: Heart Rhythm Society, San Francisco, May 2016.
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Troczka, Bartlomiej J., Williams, Alan John, Williamson, Martin S., Field, Linda M., Lüemmen, Peter and Davies, T.G. Emyr 2015. Stable expression and functional characterisation of the diamondback moth ryanodine receptor G4946E variant conferring resistance to diamide insecticides. Scientific Reports 5 , 14680. 10.1038/srep14680

Bannister, Mark L., Thomas, N. Lowri ORCID: https://orcid.org/0000-0001-8822-8576, Sikkel, Markus B., Mukherjee, Saptarshi, Maxwell, Chloe, MacLeod, Kenneth T., George, Christopher H. and Williams, Alan J. 2015. The mechanism of flecainide action in CPVT does not involve a direct effect on RyR2. Circulation Research 116 (8) , pp. 1324-1335. 10.1161/CIRCRESAHA.116.305347

Troczka, B. J., Williams, Alan John, Bass, C., Williamson, M. S., Field, L. M. and Davies, T. G. E. 2015. Molecular cloning, characterisation and mRNA expression of the ryanodine receptor from the peach-potato aphid, Myzus persicae. Gene 556 (2) , pp. 106-112. 10.1016/j.gene.2014.11.035
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Mukherjee, Saptarshi, Thomas, Nia Lowri ORCID: https://orcid.org/0000-0001-8822-8576 and Williams, Alan John 2014. Insights into the gating mechanism of the ryanodine-modified human cardiac Ca2+- release channel (ryanodine receptor 2). Molecular Pharmacology 86 (3) , pp. 318-329. 10.1124/mol.114.093757

Zissimopoulos, Spyros, Viero, Cedric, Seidel, Monika, Cumbes, Bevan ORCID: https://orcid.org/0000-0001-8529-0040, White, Judith, Cheung, Iris, Stewart, Richard, Jeyakumar, Lois, Fleischer, Sidney, Mukherjee, Saptarshi, Thomas, Nia Lowri ORCID: https://orcid.org/0000-0001-8822-8576, Williams, Alan John and Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547 2013. Amino-terminus oligomerization regulates cardiac ryanodine receptor function. Journal of Cell Science n/a 10.1242/​jcs.133538

Euden, Joanne ORCID: https://orcid.org/0000-0002-2844-6878, Mason, Sammy and Williams, Alan John 2013. Functional characterization of the cardiac Ryanodine receptor pore-forming region. PLoS ONE 8 (6) , e66542. 10.1371/journal.pone.0066542
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Euden, Joanne ORCID: https://orcid.org/0000-0002-2844-6878, Mason, Sammy, Viero, Cedric, Thomas, Nia Lowri ORCID: https://orcid.org/0000-0001-8822-8576 and Williams, Alan John 2013. Investigations of the contribution of a putative glycine hinge to ryanodine receptor channel gating. Journal of Biological Chemistry 288 (23) , pp. 16671-16679. 10.1074/jbc.M113.465310
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Sikkel, M., Collins, T., Rowlands, C., Shah, M., O'Gara, P., Williams, Alan John, Harding, S., Lyon, A. and MacLeod, K. 2013. Flecainide reduces Ca2+ spark and wave frequency via inhibition of the sarcolemmal sodium current. Cardiovascular Research 98 (2) , pp. 286-296. 10.1093/cvr/cvt012

Zissimopoulos, Spyros, Viero, C., Seidel, Monika, Cumbes, Bevan ORCID: https://orcid.org/0000-0001-8529-0040, White, Judith, Cheung, I., Stewart, R., Jeyakumar, L., Fleischer, S., Mukherjee, Saptarshi, Thomas, Nia Lowri ORCID: https://orcid.org/0000-0001-8822-8576, Williams, Alan John and Lai, Francis ORCID: https://orcid.org/0000-0003-2852-8547 2013. N-terminus oligomerization regulates the function of cardiac ryanodine receptors. Journal of Cell Science 126 (21) , pp. 5042-5051. 10.1242/jcs.133538

Mason, Sammy, Viero, Cedric, Euden, Joanne ORCID: https://orcid.org/0000-0002-2844-6878, Bannister, Mark, West, Duncan, Chen, S. R. Wayne and Williams, Alan John 2012. The contribution of hydrophobic residues in the pore-forming region of the ryanodine receptor channel to block by large tetraalkylammonium cations and Shaker B inactivation peptides. The Journal of General Physiology 140 (3) , pp. 325-339. 10.1085/jgp.201210851
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Mukherjee, Saptarshi, Thomas, Nia Lowri ORCID: https://orcid.org/0000-0001-8822-8576 and Williams, Alan John 2012. A mechanistic description of gating of the human cardiac ryanodine receptor in a regulated minimal environment. The Journal of General Physiology 140 (2) , pp. 139-158. 10.1085/jgp.201110706
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Thomas, Nia Lowri ORCID: https://orcid.org/0000-0001-8822-8576 and Williams, Alan John 2012. Pharmacology of ryanodine receptors and Ca2+-induced Ca2+ release. Wiley Interdisciplinary Reviews: Membrane Transport and Signaling 1 (4) , pp. 383-397. 10.1002/wmts.34

Zissimopoulos, Spyros, Seifan, Sara, Maxwell, Chloe, Williams, Alan John and Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547 2012. Disparities in the association of the ryanodine receptor and the FK506-binding proteins in mammalian heart. Journal of Cell Science 125 (7) , pp. 1759-1769. 10.1242/jcs.098012

Viero, Cedric, Thomas, Nia Lowri ORCID: https://orcid.org/0000-0001-8822-8576, Euden, Joanne ORCID: https://orcid.org/0000-0002-2844-6878, Mason, Sammy A., George, Christopher H. and Williams, Alan J. 2012. Techniques and methodologies to study the ryanodine receptor at the molecular, subcellular and cellular level. Calcium Signaling, Advances in Experimental and Medical Biology, Dordrecht: Springer, pp. 183-215. (10.1007/978-94-007-2888-2_8)

Viero, Cedric, Thomas, Nia Lowri ORCID: https://orcid.org/0000-0001-8822-8576, Euden, Joanne ORCID: https://orcid.org/0000-0002-2844-6878, Mason, Sammy, George, Christopher H. and Williams, Alan John 2012. Techniques and methodologies to study the ryanodine receptor at the molecular, subcellular and cellular level. Islam, Md. Shahidul, ed. Calcium Signaling, Advances in Experimental Medicine and Biology, vol. 740. Dordrecht: Springer, pp. 183-215. (10.1007/978-94-007-2888-2_8)

Carney, Joanne ORCID: https://orcid.org/0000-0002-2844-6878, Mason, Sammy A., Viero, Cedric and Williams, Alan J. 2010. The ryanodine receptor pore: Is there a consensus view? Serysheva, Irina I., ed. Structure and Function of Calcium Release Channels, Vol. 66. Current Topics in Membranes, Elsevier Academic Press In, pp. 49-67. (10.1016/S1063-5823(10)66003-6)

Thomas, Nia Lowri ORCID: https://orcid.org/0000-0001-8822-8576, Maxwell, Chloe, Mukherjee, Saptarshi and Williams, Alan John 2010. Ryanodine receptor mutations in arrhythmia: the continuing mystery of channel dysfunction. FEBS Letters 584 (10) , pp. 2153-2160. 10.1016/j.febslet.2010.01.057

Kumar, Sanjay, Hall, Roger J. C., Mani, Ali R., Moore, Kevin P., Camici, Paolo G., Rimoldi, Ornella E., Williams, Alan John and Macleod, Kenneth T. 2009. Myocardial stunning is associated with impaired calcium uptake by sarcoplasmic reticulum. Biochemical and Biophysical Research Communications 387 (1) , pp. 77-82. 10.1016/j.bbrc.2009.06.115

Meng, Xing, Wang, Guoliang, Viero, Cedric, Wang, Qiongling, Mi, Wei, Su, Xiao-Dong, Wagenknecht, Terence, Williams, Alan John, Liu, Zheng and Yin, Chang-Cheng 2009. CLIC2-RyR1 interaction and structural characterization by cryo-electron microscopy. Journal of Molecular Biology 387 (2) , pp. 320-334. 10.1016/j.jmb.2009.01.059

Mead-Savery, Fiona C., Wang, Ruiwu, Tanna-Topan, Bhavna, Chen, S. R. Wayne, Welch, William and Williams, Alan John 2009. Changes in negative charge at the luminal mouth of the pore alter ion handling and gating in the cardiac ryanodine-receptor. Biophysical journal 96 (4) , pp. 1374-1387. 10.1016/j.bpj.2008.10.054

Goddard, C. A., Ghais, N. S., Zhang, Y., Williams, Alan John, Colledge, W. H., Grace, A. A. and Huang, C. L.-H. 2008. Physiological consequences of the P2328S mutation in the ryanodine receptor (RyR2) gene in genetically modified murine hearts. Acta Physiologica 194 (2) , pp. 123-140. 10.1111/j.1748-1716.2008.01865.x

Zissimopoulos, Spyros, West, Duncan J., Williams, Alan John and Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547 2006. Ryanodine receptor interaction with the SNARE-associated protein snapin. Journal of cell science 119 (11) , pp. 2386-2397. 10.1242/jcs.02936

Ranatunga, Kishani M., Moreno-King, Tracy M., Tanna, Bhavna, Wang, Ruiwu, Chen, S. R. Wayne, Ruest, Luc, Welch, William and Williams, Alan John 2005. The Gln4863Ala mutation within a putative, pore-lining trans-membrane helix of the cardiac ryanodine receptor channel alters both the kinetics of ryanoid interaction and the subsequent fractional conductance. Molecular Pharmacology 68 , pp. 840-846. 10.1124/mol.105.012807

George, Christopher, Jundi, Hala, Thomas, Nia Lowri ORCID: https://orcid.org/0000-0001-8822-8576, Scoote, Mark, Walters, Nicola, Williams, Alan John and Lai, Francis Anthony ORCID: https://orcid.org/0000-0003-2852-8547 2004. Ryanodine receptor regulation by intramolecular interaction between cytoplasmic and transmembrane domains. Molecular biology of the cell 15 (6) , pp. 2627-2638. 10.1091/mbc.E03-09-0688
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Welch, William, Rheault, Shana, West, Duncan J. and Williams, Alan John 2004. A model of the putative pore region of the cardiac ryanodine receptor channel. Biophysical Journal 87 (4) , pp. 2335-2351. 10.1529/biophysj.104.044180
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Williams, Alan John and Mead, F. 2004. Electrostatic mechanisms underlie neomycin block of the cardiac ryanodine receptor channel (RyR2). Biophysical Journal 87 (6) , pp. 3814-3825. 10.1529/biophysj.104.049338
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Williams, Alan John, Tanna, B., Ruest, L. and Welch, W. 2003. An anionic ryanoid, 10-O-succinoylryanodol, provides insights into the mechanisms governing the interaction of ryanoids and the subsequent altered function of ryanodine-receptor channels. The Journal of General Physiology 121 (6) , pp. 551-561. 10.1085/jgp.200208753

Williams, Alan John 1984. The measurement of cardiac membrane channels following their incorporation into planar phospholipid bilayers. Harris, P.C., ed. Advances in myocardiology, New York and London: Plenum, pp. 77-84.

Williams, Alan John 1983. Mitochondria. Drake-Holland, A. J. and Noble, M. I. M., eds. Cardiac metabolism, Chichester: J. Wiley & Sons, pp. 151-171.

Ferrari, R., Williams, Alan John and Di Lisa, F. 1982. The role of mitochondrial function in the ischemic and reperfused myocardium. Caldarera, C.M. and Harris, P.C., eds. Advances in studies on heart metabolism, Bologna: CLUEB, pp. 245-255.

Williams, Alan John, Crie, A. J. and Ferrari, R. 1982. Factors influencing cardiac mitochondrial calcium transport and oxidative phosphorylation. Caldarera, C. M. and Harris, P. C., eds. Advances in studies on heart metabolism, Bologna: CLUEB, pp. 173-183.

Nayler, W. G., Mas-Oliva, J. and Williams, Alan John 1980. Sarcolemma calcium transport and drug action. Presented at: 9th International Congress of the International Society for Heart Research, New Delhi, India, 28 September - October 2 1978. Published in: Tajuddin, M. K. ed. Proceedings of the 9th international congress of the International Society for Heart Research, New Delhi, India, 28 September - October 2 1978. Advances in Myocardiology (1-2) Baltimore: University Park Press, pp. 77-94.

This list was generated on Wed Apr 23 07:46:42 2025 BST.


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