Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Browse by All Cardiff Authors

[up] Up a level
Number of items: 13.

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Bourdin, Claire, Derudas, Marco, Hamon, Nadege, Hinsinger, Karen, Kandil, Sahar ORCID: https://orcid.org/0000-0003-1806-9623, Madela, Karolina, Meneghesso, Silvia, Pertusati, Fabrizio ORCID: https://orcid.org/0000-0003-4532-9101, Serpi, Michaela ORCID: https://orcid.org/0000-0002-6162-7910, Slusarczyk, Magdalena ORCID: https://orcid.org/0000-0002-4707-7190, Chamberlain, Stanley, Kolykhalov, Alexander, Vernachio, John, Vanpouille, Christophe, Introini, Andrea, Margolis, Leonid and Balzarini, Jan 2013. Design, synthesis and biological evaluation of phosphorodiamidate prodrugs of antiviral and anticancer nucleosides. European Journal of Medicinal Chemistry 70 , pp. 326-340. 10.1016/j.ejmech.2013.09.047
file

Madela, Karolina and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2012. Progress in the development of anti-hepatitis C virus nucleoside and nucleotide prodrugs. Future Medicinal Chemistry 4 (5) , pp. 625-650. 10.4155/fmc.12.10

Madela, Karolina 2012. Design, synthesis and biological evaluation of novel anti-HCV nucleosides and nucleotides: from bench to the clinical trials. PhD Thesis, Cardiff University.
Item availability restricted.
filefile

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Madela, Karolina, Aljarah, Mohamed, Bourdin, Claire, Arrica, Maria, Barrett, Emma, Jones, Sarah Louise, Kolykhalov, Alexander, Bleiman, Blair, Bryant, K. Dawn, Ganguly, Babita, Gorovits, Elena, Henson, Geoffrey, Hunley, Damound, Hutchins, Jeff, Muhammad, Jerry, Obikhod, Aleksandr, Patti, Joseph, Walters, C. Robin, Wang, Jin, Vernachio, John, Ramamurty, Changalvala V. S., Battina, Srinivas K. and Chamberlain, Stanley 2011. Phosphorodiamidates as a promising new phosphate prodrug motif for antiviral drug discovery: application to anti-HCV agents. Journal of Medicinal Chemistry 54 (24) , pp. 8632-8645. 10.1021/jm2011673

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Madela, Karolina, Aljarah, Mohamed, Gilles, Arnaud, Battina, S. K., Ramamurty, C. V. S., Rao, C. S., Vernachio, J., Hutchins, J., Hall, A., Kolykhalov, A., Henson, G. and Chamberlain, S. 2011. Dual pro-drugs of 2 '-C-methyl guanosine monophosphate as potent and selective inhibitors of hepatitis C virus. Biorganic and Medicinal Chemistry Letters 21 (19) , pp. 6007-6012. 10.1016/j.bmcl.2011.06.013

Vernachio, John H., Bleiman, Blair, Bryant, K. Dawn, Chamberlain, Stanley, Hunley, Damound, Hutchins, Jeff, Ames, Brenda, Gorovits, Elena, Ganguly, Babita, Hall, Andrea, Kolykhalov, Alexander, Liu, Yule, Muhammad, Jerry, Raja, Nicholas, Walters, C. Robin, Wang, Jin, Williams, Karen, Patti, Joseph M., Henson, Geoffrey, Madela, Karolina, Aljarah, Mohamed, Gilles, Arnaud and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2011. INX-08189, a phosphoramidate prodrug of 6-O-Methyl-2'-C-Methyl Guanosine, is a potent inhibitor of Hepatitis C virus replication with excellent pharmacokinetic and pharmacodynamic properties. Antimicrobial Agents and Chemotherapy 55 (5) , pp. 1843-1851. 10.1128/AAC.01335-10
file

Vernachio, J., Bryant, D., Chamberlain, S. D., Gorovits, E., Ganguly, B. S., Hall, A., Henson, G. W., Hunley, D. S., Hutchins, J. T., Muhammad, J., Patti, J., Walters, C. R., Wang, J., Madela, Karolina, Aljarah, Mohamed, Jones, Sarah Louise and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2010. In vitro and in vivo metabolism of INX-189, a potent HCV inhibitor, in rat and cynomolgus monkey hepatocytes [Abstract]. Hepatology 52 (S1) , 1218A-1219A. 10.1002/hep.23997

Hall, A., Raja, N., Chamberlain, S. D., Gorovits, E., Henson, G. W., Hutchins, J. T., Muhammad, J., Patti, J., Vernachio, J., Wang, J., Madela, Karolina, Aljarah, Mohamed, Jones, Sarah Louise and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2010. Metabolite characterization of INX-189, a potent HCV inhibitor, in fresh human primary hepatocytes and human liver and kidney cell lines [abstract 1874]. Hepatology 52 (S1) , 1211A-1211A. 10.1002/hep.23996

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Madela, Karolina, Aljarah, Mohamed, Gilles, Arnaud, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Zonta, Nicola, Chamberlain, Stanley, Vernachio, John, Hutchins, Jeff and Hall, Andrea 2010. Design, synthesis and evaluation of a novel double pro-drug: INX-08189. A new clinical candidate for hepatitis C virus. Biorganic and Medicinal Chemistry Letters 20 (16) , pp. 4850-4854. 10.1016/j.bmcl.2010.06.094

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Gilles, Arnaud, Madela, Karolina, Aljarah, Mohamed, Holl, Sabrina, Jones, Sarah Louise, Vernachio, John, Hutchins, Jeff, Ames, Brenda, Bryant, K. Dawn, Gorovits, Elena, Ganguly, Babita, Hunley, Damound, Hall, Andrea, Kolykhalov, Alexander, Liu, Yule, Muhammad, Jerry, Raja, Nicholas, Walters, Robin, Wang, Jin, Chamberlain, Stanley and Henson, Geoffrey 2010. Phosphoramidate ProTides of 2'-C-Methylguanosine as highly potent inhibitors of hepatitis C virus. Study of their in vitro and in vivo properties. Journal of Medicinal Chemistry 53 (13) , pp. 4949-4957. 10.1021/jm1003792

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Perrone, Plinio, Madela, Karolina and Neyts, Johan 2009. The phosphoramidate ProTide approach greatly enhances the activity of beta-2 '-C-methylguanosine against hepatitis C virus. Biorganic and Medicinal Chemistry Letters 19 (15) , pp. 4316-4320. 10.1016/j.bmcl.2009.05.122

Hutchins, J., Chanberlain, S., Chang, C., Ganguly, B., Gorovits, E., Hall, A., Henson, G., Kolykhalov, A., Liu, Y., Muhammad, J., Perrone, P., Gilles, A., Holl, Sabrina, Madela, Karolina, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Patti, J. 2009. In Vitro Activity and In Vivo Pharmacokinetics of Highly Potent Phosphoramidate Nucleoside Analogue Inhibitors of Hepatitis C NS5B. Antiviral Research 82 (2) , A28. 10.1016/j.antiviral.2009.02.047

Madela, Karolina, Perrone, P., Gilles, A., Neyts, J. and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2009. Phosphoramidate Protides Greatly Enhance the Anti-HCV Activity of 2 '-Methylguanosine. Antiviral Research 82 (2) , A29-A30. 10.1016/j.antiviral.2009.02.051

This list was generated on Tue Apr 15 07:47:54 2025 BST.


Maintained by Cardiff University Information Services