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Single-cell RNAseq identifies clonally expanded antigen-specific T-cells following intradermal injection of gold nanoparticles loaded with diabetes autoantigen in humans.
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Hanna, Stephanie J., Powell, Wendy E. ORCID: https://orcid.org/0000-0002-4670-1406, Long, Anna E., Robinson, Emma J. S., Davies, Joanne, Megson, Clare, Howell, Alexandra, Jones, Taz J., Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Dayan, Colin M. ORCID: https://orcid.org/0000-0002-6557-3462, Williams, Alistair J. K., Gillespie, Kathleen M. and Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845
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Slow progressors to type 1 diabetes lose islet autoantibodies over time, have few islet antigen-specific CD8+ T cells and exhibit a distinct CD95hi B cell phenotype.
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