Beware of N-Benzoyloxybenzamides

Cubitt, Jonathan, Davies, Mari, Riseley, Ross, Evans, Gabrielle, Gardiner, Sian E., Kariuki, Benson M. ORCID: https://orcid.org/0000-0002-8658-3897, Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377, Lloyd-Evans, Emyr ORCID: https://orcid.org/0000-0002-3626-1611, Waller-Evans, Helen ORCID: https://orcid.org/0000-0003-4133-6064 and Jones, D. Heulyn 2024. Beware of N-Benzoyloxybenzamides. Molecules 29 (21) , 5143. 10.3390/molecules29215143

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Abstract

Following a High-Throughput Screening campaign to discover inhibitors of acid ceramidase, we report the novel and extremely potent covalent inhibitor, 1. Following resynthesis and stability monitoring, we discovered that 1 is chemically unstable and reacts with DMSO at room temperature. This mode of decomposition is likely general for this class of compound, and we urge caution for their use in drug discovery research.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry Medicine
Publisher:	MDPI
ISSN:	1420-3049
Date of First Compliant Deposit:	1 November 2024
Date of Acceptance:	28 October 2024
Last Modified:	15 Nov 2024 09:25
URI:	https://orca.cardiff.ac.uk/id/eprint/173605

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