Telomere length profiles in primary human peritoneal mesothelial cells are consistent with senescence

Lopez Anton, Melisa, Rudolf, Andras, Baird, Duncan Martin ORCID: https://orcid.org/0000-0001-8408-5467, Roger, Laureline, Robinson, Rhiannon, Witowski, Janusz, Fraser, Donald James ORCID: https://orcid.org/0000-0003-0102-9342 and Bowen, Timothy ORCID: https://orcid.org/0000-0001-6050-0435 2017. Telomere length profiles in primary human peritoneal mesothelial cells are consistent with senescence. Mechanisms of Ageing and Development 164 , pp. 37-40. 10.1016/j.mad.2017.03.010

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Abstract

Mesothelial cell (MC) senescence contributes to malignancy and tissue fibrosis. The role of telomere erosion in MC senescence remains controversial, with evidence for both telomere-dependent and telomere-independent mechanisms reported. Single telomere length analysis revealed considerable telomere length heterogeneity in freshly isolated human peritoneal MCs, reflecting a heterogeneous proliferative history and providing high-resolution evidence for telomere-dependent senescence. By contrast the attenuated replicative lifespan, lack of telomere erosion and induction of p16 expression in in vitro-aged cells was consistent with stress-induced senescence. Given the potential pathophysiological impact of senescence in mesothelial tissues, high-resolution MC telomere length analysis may provide clinically useful information.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Uncontrolled Keywords:	Mesothelium Premature senescence Single telomere length analysis
Publisher:	Elsevier
ISSN:	0047-6374
Date of First Compliant Deposit:	25 May 2017
Date of Acceptance:	22 March 2017
Last Modified:	25 Nov 2024 17:45
URI:	https://orca.cardiff.ac.uk/id/eprint/100873

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