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Telomere length profiles in primary human peritoneal mesothelial cells are consistent with senescence

Lopez Anton, Melisa, Rudolf, Andras, Baird, Duncan Martin ORCID:, Roger, Laureline, Robinson, Rhiannon, Witowski, Janusz, Fraser, Donald James ORCID: and Bowen, Timothy ORCID: 2017. Telomere length profiles in primary human peritoneal mesothelial cells are consistent with senescence. Mechanisms of Ageing and Development 164 , pp. 37-40. 10.1016/j.mad.2017.03.010

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Mesothelial cell (MC) senescence contributes to malignancy and tissue fibrosis. The role of telomere erosion in MC senescence remains controversial, with evidence for both telomere-dependent and telomere-independent mechanisms reported. Single telomere length analysis revealed considerable telomere length heterogeneity in freshly isolated human peritoneal MCs, reflecting a heterogeneous proliferative history and providing high-resolution evidence for telomere-dependent senescence. By contrast the attenuated replicative lifespan, lack of telomere erosion and induction of p16 expression in in vitro-aged cells was consistent with stress-induced senescence. Given the potential pathophysiological impact of senescence in mesothelial tissues, high-resolution MC telomere length analysis may provide clinically useful information.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Uncontrolled Keywords: Mesothelium Premature senescence Single telomere length analysis
Publisher: Elsevier
ISSN: 0047-6374
Date of First Compliant Deposit: 25 May 2017
Date of Acceptance: 22 March 2017
Last Modified: 07 Nov 2023 07:05

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