Passaes, Caroline, Millet, Antoine, Madelain, Vincent, Monceaux, Valérie, David, Annie, Versmisse, Pierre, Sylla, Naya, Gostick, Emma, Llewellyn-Lacey, Sian, Price, David A. ![]() ![]() |
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Abstract
Highly efficient CD8+ T cells are associated with natural HIV control, but it has remained unclear how these cells are generated and maintained. We have used a macaque model of spontaneous SIVmac251 control to monitor the development of efficient CD8+ T cell responses. Our results show that SIV-specific CD8+ T cells emerge during primary infection in all animals. The ability of CD8+ T cells to suppress SIV is suboptimal in the acute phase but increases progressively in controller macaques before the establishment of sustained low-level viremia. Controller macaques develop optimal memory-like SIV-specific CD8+ T cells early after infection. In contrast, a persistently skewed differentiation phenotype characterizes memory SIV-specific CD8+ T cells in non-controller macaques. Accordingly, the phenotype of SIV-specific CD8+ T cells defined early after infection appears to favor the development of protective immunity in controllers, whereas SIV-specific CD8+ T cells in non-controllers fail to gain antiviral potency, feasibly as a consequence of early defects imprinted in the memory pool.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine |
Publisher: | Elsevier |
ISSN: | 2211-1247 |
Date of First Compliant Deposit: | 14 October 2020 |
Date of Acceptance: | 28 August 2020 |
Last Modified: | 12 May 2023 13:48 |
URI: | https://orca.cardiff.ac.uk/id/eprint/135584 |
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