Crosstalk between circadian rhythms and the microbiota

Pearson, James Alexander ORCID: https://orcid.org/0000-0002-2867-2269, Wong, Florence Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, Li 2020. Crosstalk between circadian rhythms and the microbiota. Immunology 161 (4) , pp. 278-290. 10.1111/imm.13278

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Abstract

Circadian rhythms influence daily molecular oscillations in gene/protein expression and aspects of biology and physiology, including behaviour, body temperature and sleep–wake cycles. These circadian rhythms have been associated with a number of metabolic, immune and microbial changes that correlate with health and susceptibility to disease, including infection. While light is the main inducer of circadian rhythms, other factors, including the microbiota, can have important effects on peripheral rhythms. The microbiota have been of significant interest to many investigators over the past decade, with the development of molecular techniques to identify large numbers of species and their function. These studies have shown microbial associations with disease susceptibility, and some of these have demonstrated that alterations in microbiota cause disease. Microbial circadian oscillations impact host metabolism and immunity directly and indirectly. Interestingly, microbial oscillations also regulate host circadian rhythms, and the host circadian rhythms in turn modulate microbial composition. Thus, it is of considerable interest and importance to understand the crosstalk between circadian rhythms and microbiota and especially the microbial influences on the host. In this review, we aim to discuss the role of circadian microbial oscillations and how they influence host immunity. In addition, we discuss how host circadian rhythms can also modulate microbial rhythms. We also discuss potential connections between microbes and circadian rhythms and how these may be used therapeutically to maximize clinical success.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Additional Information:	Attribution 4.0 International (CC BY 4.0)
Publisher:	Wiley
ISSN:	0019-2805
Funders:	MRC
Date of First Compliant Deposit:	28 October 2020
Date of Acceptance:	30 September 2020
Last Modified:	05 May 2023 14:19
URI:	https://orca.cardiff.ac.uk/id/eprint/136002

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