Genetic and phenotypic features of Schizophrenia in the UK Biobank

Legge, Sophie, Pardinas, Antonio ORCID: https://orcid.org/0000-0001-6845-7590, Woolway, Grace, Rees, Elliott ORCID: https://orcid.org/0000-0002-6168-9222, Cardno, Alastair, Escott-Price, Valentina ORCID: https://orcid.org/0000-0003-1784-5483, Holmans, Peter ORCID: https://orcid.org/0000-0003-0870-9412, Kirov, George ORCID: https://orcid.org/0000-0002-3427-3950, Owen, Michael ORCID: https://orcid.org/0000-0003-4798-0862, O'Donovan, Michael ORCID: https://orcid.org/0000-0001-7073-2379 and Walters, James ORCID: https://orcid.org/0000-0002-6980-4053 2024. Genetic and phenotypic features of Schizophrenia in the UK Biobank. JAMA Psychiatry 10.1001/jamapsychiatry.2024.0200

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Abstract

Question How do individuals with a diagnosis of schizophrenia recruited in a large volunteer-based research resource (UK Biobank) differ from those in the Psychiatric Genomics Consortium (PGC) or those recruited from clinical settings? Findings In this cross-sectional study including more than 517 000 individuals, liability to schizophrenia in the UK Biobank had a high genetic correlation with the PGC. Compared with 4 clinically ascertained schizophrenia samples, UK Biobank participants with schizophrenia had significantly lower schizophrenia genetic liability as indexed by polygenic risk score, lower rates of copy number variants, and fewer phenotypic features of poor outcome. Meaning In this study, individuals with schizophrenia in the UK Biobank had features of less severe illness, which indicates that registries such as the UK Biobank can help to capture the full range of heterogeneity in schizophrenia research.

Item Type:	Article
Date Type:	Published Online
Status:	In Press
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Publisher:	American Medical Association
ISSN:	2168-622X
Date of First Compliant Deposit:	18 January 2024
Date of Acceptance:	12 January 2024
Last Modified:	18 Jun 2024 15:01
URI:	https://orca.cardiff.ac.uk/id/eprint/165636

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