Cutting edge: murine CD59a modulates antiviral CD4+ T cell activity in a complement-independent manner

Longhi, M. Paula, Baalasubramanian, Sivasankar, Omidvar, Nader, Morgan, Bryan Paul ORCID: https://orcid.org/0000-0003-4075-7676 and Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004 2005. Cutting edge: murine CD59a modulates antiviral CD4+ T cell activity in a complement-independent manner. Journal of Immunology 175 (11) , pp. 7098-7102.

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Abstract

CD59 blocks formation of the membrane attack complex of complement by inhibiting binding of C9 to the C5b-8 complex. To investigate a role for CD59 in promoting T cell responses, we compared T cell activation in CD59a-deficient (Cd59a-/-) and wild-type (WT) mice after in vitro stimulation and after infection with rVV. Virus-specific CD4+ T cell responses were significantly enhanced in Cd59a-/- mice compared with WT mice. Similarly, Cd59a-/- T cells responded more vigorously to in vitro stimulation with CD3-specific Abs compared with WT mice. This effect of CD59a on T cell proliferation was found to be complement-independent. Collectively, these results demonstrate that CD59a down-modulates CD4+ T cell activity in vitro and in vivo, thereby revealing another link between complement regulators and T cell activation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Systems Immunity Research Institute (SIURI)
Publisher:	American Association of Immunologists
ISSN:	0022-1767
Related URLs:	http://www.ncbi.nlm.nih.gov/entrez/query...
Last Modified:	17 Oct 2022 08:29
URI:	https://orca.cardiff.ac.uk/id/eprint/270

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