Longhi, M. Paula, Baalasubramanian, Sivasankar, Omidvar, Nader, Morgan, Bryan Paul  ORCID: https://orcid.org/0000-0003-4075-7676 and Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004
2005.
Cutting edge: murine CD59a modulates antiviral CD4+ T cell activity in a complement-independent manner.
Journal of Immunology
175
(11)
, pp. 7098-7102.
|
Abstract
CD59 blocks formation of the membrane attack complex of complement by inhibiting binding of C9 to the C5b-8 complex. To investigate a role for CD59 in promoting T cell responses, we compared T cell activation in CD59a-deficient (Cd59a-/-) and wild-type (WT) mice after in vitro stimulation and after infection with rVV. Virus-specific CD4+ T cell responses were significantly enhanced in Cd59a-/- mice compared with WT mice. Similarly, Cd59a-/- T cells responded more vigorously to in vitro stimulation with CD3-specific Abs compared with WT mice. This effect of CD59a on T cell proliferation was found to be complement-independent. Collectively, these results demonstrate that CD59a down-modulates CD4+ T cell activity in vitro and in vivo, thereby revealing another link between complement regulators and T cell activation.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine Research Institutes & Centres > Systems Immunity Research Institute (SIURI) |
| Publisher: | American Association of Immunologists |
| ISSN: | 0022-1767 |
| Related URLs: | |
| Last Modified: | 17 Oct 2022 08:29 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/270 |
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