The complotype: dictating risk for inflammation and infection

Harris, Claire Louise, Heurich, Meike ORCID: https://orcid.org/0000-0003-0105-2702, Rodriguez de Cordoba, Santiago and Morgan, Bryan Paul ORCID: https://orcid.org/0000-0003-4075-7676 2012. The complotype: dictating risk for inflammation and infection. Trends in Immunology 33 (10) , pp. 513-521. 10.1016/j.it.2012.06.001

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Abstract

Complement is a key component of immune defence against infection; it potently drives inflammation at sites of pathology and is essential for killing of pathogens. Genetic linkage of common complement polymorphisms to disease has advanced the concept that subtle changes in complement activity significantly affect disease risk. Functional analyses of disease-linked polymorphic variants demonstrate that, although individual polymorphisms cause only small changes in activity, when combined, the aggregate effects are large. The inherited set of common variants, the complotype, thus has a major impact on susceptibility to inflammatory and infectious diseases. Assessing the complotype of an individual will aid prediction of disease risk and inform intervention to reduce or eliminate risk.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Pharmacy Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	complement, complotype, inflammation, alternative pathway
Publisher:	Elsevier
ISSN:	1471-4906
Last Modified:	21 Oct 2022 10:41
URI:	https://orca.cardiff.ac.uk/id/eprint/41045

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