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Complement C4, C4A and C4a – what they do and how they differ.
Brain, Behavior, & Immunity - Health
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Byrne, Jonah F., Healy, Colm, Föcking, Melanie, Heurich, Meike ORCID: https://orcid.org/0000-0003-0105-2702, Susai, Subash Raj, Mongan, David, Wynne, Kieran, Kodosaki, Eleftheria, Woods, Scott W., Cornblatt, Barbara A., Stone, William S., Mathalon, Daniel H., Bearden, Carrie E., Cadenhead, Kristin S., Addington, Jean, Walker, Elaine F., Cannon, Tyrone D., Cannon, Mary, Jeffries, Clark, Perkins, Diana and Cotter, David R.
2024.
Plasma complement and coagulation proteins as prognostic factors of negative symptoms: An analysis of the NAPLS 2 and 3 studies.
Brain, Behavior, and Immunity
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10.1016/j.bbi.2024.03.049
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Kodosaki, Eleftheria, Healy, Colm, Byrne, Jonah F., Foecking, Melanie, Cannon, Mary, Perkins, Diana O., Cotter, David and Heurich, Meike ORCID: https://orcid.org/0000-0003-0105-2702
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Sample processing time but not storage time affects complement activation markers C4a, C4d, C3a, C3d, Bb, C5a, and sC5b-9 levels in EDTA-plasma of individuals at clinical high-risk for psychosis.
Biomarkers in Neuropsychiatry
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, 100097.
10.1016/j.bionps.2024.100097
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Byrne, Jonah F., Healy, Colm, Föcking, Melanie, Susai, Subash Raj, Mongan, David, Wynne, Kieran, Kodosaki, Eleftheria, Heurich-Sevcenco, Meike ORCID: https://orcid.org/0000-0003-0105-2702, de Haan, Lieuwe, Hickie, Ian B., Smesny, Stefan, Thompson, Andrew, Markulev, Connie, Young, Alison Ruth, Schäfer, Miriam R., Riecher-Rössler, Anita, Mossaheb, Nilufar, Berger, Gregor, Schlögelhofer, Monika, Nordentoft, Merete, Chen, Eric Y. H., Verma, Swapna, Nieman, Dorien H., Woods, Scott W., Cornblatt, Barbara A., Stone, William S., Mathalon, Daniel H., Bearden, Carrie E., Cadenhead, Kristin S., Addington, Jean, Walker, Elaine F., Cannon, Tyrone D., Cannon, Mary, McGorry, Pat, Amminger, Paul, Cagney, Gerard, Nelson, Barnaby, Jeffries, Clark, Perkins, Diana and Cotter, David R.
2024.
Proteomic biomarkers for the prediction of transition to psychosis in individuals at clinical high risk: A multi-cohort model development study.
Schizophrenia Bulletin
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10.1093/schbul/sbad184
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Healy, Colm, Byrne, Jonah, Raj Suasi, Subash, Föcking, Melanie, Mongan, David, Kodosaki, Eleftheria, Heurich, Meike ORCID: https://orcid.org/0000-0003-0105-2702, Cagney, Gerard, Wynne, Kieran, Bearden, Carrie E., Woods, Scott W., Cornblatt, Barbara, Mathalon, Daniel, Stone, William, Cannon, Tyrone D., Addington, Jean, Cadenhead, Kristin S., Perkins, Diana, Jeffries, Clark and Cotter, David
2024.
Differential expression of haptoglobin in individuals at clinical high risk of psychosis and its association with global functioning and clinical symptoms.
Brain, Behavior, and Immunity
117
, pp. 175-180.
10.1016/j.bbi.2023.12.018
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Heurich, Meike ORCID: https://orcid.org/0000-0003-0105-2702 and McCluskey, Geneviève
2023.
Complement and coagulation crosstalk - Factor H in the spotlight.
Immunobiology
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Cropley, V.L., Kittel, M., Heurich-Sevcenco, M. ORCID: https://orcid.org/0000-0003-0105-2702, Föcking, M., Leweke, F.M. and Pantelis, C.
2023.
Complement proteins are elevated in blood serum but not CSF in clinical high-risk and antipsychotic-naïve first-episode psychosis.
Brain, Behavior, and Immunity
113
, pp. 136-144.
10.1016/j.bbi.2023.07.004
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Susai, Subash Raj, Föcking, Melanie, Mongan, David, Heurich, Meike ORCID: https://orcid.org/0000-0003-0105-2702, Coutts, Fiona, Egerton, Alice, Whetton, Tony, Winter-van Rossum, Inge, Unwin, Richard D., Pollak, Thomas A., Weiser, Mark, Leboyer, Marion, Rujescu, Dan, Byrne, Jonah F., Gifford, George W., Dazzan, Paola, Koutsouleris, Nikolaos, Kahn, René S., Cotter, David R. and McGuire, Philip
2023.
Association of complement and coagulation pathway proteins with treatment response in first-episode psychosis: a longitudinal analysis of the OPTiMiSE clinical trial.
Schizophrenia Bulletin: The Journal of Psychoses and Related Disorders
49
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10.1093/schbul/sbac201
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Susai, Subash Raj, Healy, Colm, Mongan, David, Heurich-Sevcenco, Meike ORCID: https://orcid.org/0000-0003-0105-2702, Byrne, Jonah F., Cannon, Mary, Cagney, Gerard, Wynne, Kieran, Markulev, Connie, Schäfer, Miriam R., Berger, Maximus, Mossaheb, Nilufar, Schlögelhofer, Monika, Smesny, Stefan, Hickie, Ian B., Berger, Gregor E., Chen, Eric Y. H., de Haan, Lieuwe, Nieman, Dorien H., Nordentoft, Merete, Riecher-Rössler, Anita, Verma, Swapna, Street, Rebekah, Thompson, Andrew, Yung, Alison Ruth, Nelson, Barnaby, McGorry, Patrick D., Föcking, Melanie, Amminger, G. Paul and Cotter, David
2022.
Evidence that complement and coagulation proteins are mediating the clinical response to omega-3 fatty acids: A mass spectrometry-based investigation in subjects at clinical high-risk for psychosis.
Translational Psychiatry
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10.1038/s41398-022-02217-0
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Heurich, Meike ORCID: https://orcid.org/0000-0003-0105-2702, Föcking, Melanie, Mongan, David, Cagney, Gerard and Cotter, David R.
2022.
Dysregulation of complement and coagulation pathways: emerging mechanisms in the development of psychosis.
Molecular Psychiatry
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10.1038/s41380-021-01197-9
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Baker, Alexander T., Boyd, Ryan J., Sarkar, Daipayan, Teijeira Crespo, Alicia, Chan, Chun Kit, Bates, Emily, Waraich, Kasim, Vant, John, Wilson, Eric, Truong, Chloe D., Lipka-Lloyd, Magdalena, Fromme, Petra, Vermaas, Josh, Williams, Dewight, Machiesky, LeeAnn, Heurich, Meike ORCID: https://orcid.org/0000-0003-0105-2702, Nagalo, Bolni M., Coughlan, Lynda, Umlauf, Scott, Chiu, Po-Lin, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Cohen, Taylor S., Parker, Alan L. ORCID: https://orcid.org/0000-0002-9302-1761, Singharoy, Abhishek and Borad, Mitesh J.
2021.
ChAdOx1 interacts with CAR and PF4 with implications for thrombosis with thrombocytopenia syndrome.
Science Advances
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Pathare, Navichandra, Szakmany, Tamas ORCID: https://orcid.org/0000-0003-3632-8844, Hall, Judith E. ORCID: https://orcid.org/0000-0002-6770-7372 and Heurich, Meike ORCID: https://orcid.org/0000-0003-0105-2702
2021.
Plasma IgM levels differentiate between survivors and non-survivors of culture-positive and culture-negative sepsis and SIRS: a pilot study.
Journal of Clinical Medicine
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, 5391.
10.3390/jcm10225391
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Howes, Oliver, Cummings, Connor and Heurich, Meike ORCID: https://orcid.org/0000-0003-0105-2702
2021.
Translation from genes to mechanism in schizophrenia: are immune-synaptic interactions the missing link?
Biological Psychiatry
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10.1016/j.biopsych.2021.08.014
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Flude, Ben M., Nannetti, Giulio ORCID: https://orcid.org/0000-0003-3227-1537, Mitchell, Paige, Compton, Nina, Richards, Chloe, Heurich, Meike ORCID: https://orcid.org/0000-0003-0105-2702, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Ferla, Salvatore ORCID: https://orcid.org/0000-0002-5918-9237 and Bassetto, Marcella ORCID: https://orcid.org/0000-0002-2491-5868
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Targeting the complement serine protease MASP-2 as a therapeutic strategy for coronavirus infections.
Viruses
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Mongan, David, Föcking, Melanie, Healy, Colm, Susai, Subash Raj, Heurich, Meike ORCID: https://orcid.org/0000-0003-0105-2702, Wynne, Kieran, Nelson, Barnaby, McGorry, Patrick D., Amminger, G. Paul, Nordentoft, Merete, Krebs, Marie-Odile, Riecher-Rössler, Anita, Bressan, Rodrigo A., Barrantes-Vidal, Neus, Borgwardt, Stefan, Ruhrmann, Stephan, Sachs, Gabriele, Pantelis, Christos, van der Gaag, Mark, de Haan, Lieuwe, Valmaggia, Lucia, Pollak, Thomas A., Kempton, Matthew J., Rutten, Bart P. F., Whelan, Robert, Cannon, Mary, Zammit, Stan ORCID: https://orcid.org/0000-0002-2647-9211, Cagney, Gerard, Cotter, David R. and McGuire, Philip
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Development of proteomic prediction models for transition to psychotic disorder in the clinical high-risk state and psychotic experiences in adolescence.
JAMA Psychiatry
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Madrid-Gambin, Francisco, Föcking, Melanie, Sabherwal, Sophie, Heurich, Meike ORCID: https://orcid.org/0000-0003-0105-2702, English, Jane A., O'Gorman, Aoife, Suvitaival, Tommi, Ahonen, Linda, Cannon, Mary, Lewis, Glynn, Mattila, Ismo, Scaife, Caitriona, Madden, Sean, Hyötyläinen, Tuulia, Orešič, Matej, Zammit, Stanley ORCID: https://orcid.org/0000-0002-2647-9211, Cagney, Gerard, Cotter, David R. and Brennan, Lorraine
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Integrated lipidomics and proteomics point to early blood-based changes in childhood preceding later development of psychotic experiences: evidence from the Avon Longitudinal Study of Parents and Children.
Biological Psychiatry
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Föcking, Melanie, Sabherwal, Sophie, Cates, Hannah M., Scaife, Caitriona, Dicker, Patrick, Hryniewiecka, Magdalena, Wynne, Kieran, Rutten, Bart P. F., Lewis, Glyn, Cannon, Mary, Nestler, Eric J., Heurich-Sevcenco, Meike ORCID: https://orcid.org/0000-0003-0105-2702, Cagney, Gerard, Zammit, Stanley ORCID: https://orcid.org/0000-0002-2647-9211 and Cotter, David R.
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Complement pathway changes at age 12 are associated with psychotic experiences at age 18 in a longitudinal population-based study: evidence for a role of stress.
Molecular Psychiatry
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Martínez-Barricarte, Rubén, Heurich-Sevcenco, Meike ORCID: https://orcid.org/0000-0003-0105-2702, López-Perrote, Andrés, Tortajada, Agustin, Pinto, Sheila, López-Trascasa, Margarita, Sánchez-Corral, Pilar, Morgan, B. Paul ORCID: https://orcid.org/0000-0003-4075-7676, Llorca, Oscar, Harris, Claire L. and Rodríguez de Córdoba, Santiago
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The molecular and structural bases for the association of complement C3 mutations with atypical hemolytic uremic syndrome.
Molecular Immunology
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10.1016/j.molimm.2015.03.248
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Szakmany, Tamas ORCID: https://orcid.org/0000-0003-3632-8844 and Heurich-Sevcenco, Meike ORCID: https://orcid.org/0000-0003-0105-2702
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Immunomodulation in sepsis - why blunting the response doesn't work?
Journal of Infection
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10.1016/j.jinf.2015.04.019
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Ruseva, M.M. and Heurich-Sevcenco, Meike ORCID: https://orcid.org/0000-0003-0105-2702
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Purification and characterization of human and mouse complement C3.
Gadjeva, Mihaela, ed.
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Vol. 1100.
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Heurich, Meike ORCID: https://orcid.org/0000-0003-0105-2702, Altintas, Zeynep and Tothill, Ibtisam
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Computational Design of Peptide Ligands for Ochratoxin A.
Toxins
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10.3390/toxins5061202
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Harris, Claire Louise, Heurich, Meike ORCID: https://orcid.org/0000-0003-0105-2702, Rodriguez de Cordoba, Santiago and Morgan, Bryan Paul ORCID: https://orcid.org/0000-0003-4075-7676
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The complotype: dictating risk for inflammation and infection.
Trends in Immunology
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Heurich, Meike ORCID: https://orcid.org/0000-0003-0105-2702, Martinez-Barricarte, Ruben, Francis, Nigel ORCID: https://orcid.org/0000-0002-4706-4795, Roberts, Dawn L., Rodriguez de Cordoba, Santiago, Morgan, Bryan Paul ORCID: https://orcid.org/0000-0003-4075-7676 and Harris, Claire Louise
2011.
Common polymorphisms in C3, factor B, and factor H collaborate to determine systemic complement activity and disease risk.
Proceedings of the National Academy of Sciences of the United States of America
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10.1073/pnas.1019338108
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Martínez-Barricarte, Rubén, Heurich, Meike ORCID: https://orcid.org/0000-0003-0105-2702, Valdes-Cañedo, Francisco, Vazquez-Martul, Eduardo, Torreira, Eva, Montes, Tamara, Tortajada, Agustín, Pinto, Sheila, Lopez-Trascasa, Margarita, Morgan, Bryan Paul ORCID: https://orcid.org/0000-0003-4075-7676, Llorca, Oscar, Harris, Claire Louise and Rodríguez de Córdoba, Santiago
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Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation.
Journal of Clinical Investigation
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