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Number of items: 27.

Jones, Rachel-Ann ORCID: https://orcid.org/0000-0001-9792-7483, Dunlop, Elaine ORCID: https://orcid.org/0000-0002-9209-7561, Champion, Jesse, Doubleday, Peter F., Claessens, Tijs, Jalali, Zahra, Seifan, Sara, Perry, Iain, Giles, Peter ORCID: https://orcid.org/0000-0003-3143-6854, Harrison, Oliver, Coull, Barry J., Houweling, Arjan C., Pause, Arnim, Ballif, Bryan A. and Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 2025. Characterizing the tumor suppressor activity of FLCN in Birt-Hogg-Dubé syndrome through transcriptiomic and proteomic analysis. Oncogene 44 , pp. 1833-1843. 10.1038/s41388-025-03325-z
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Mantoan Ritter, Laura, Annear, Nicholas M. P., Baple, Emma L., Ben-Chaabane, Leila Y., Bodi, Istvan, Brosson, Lauren, Cadwgan, Jill E., Coslett, Bryn, Crosby, Andrew H., Davies, D. Mark, Daykin, Nicola, Dedeurwaerdere, Stefanie, Dühring Fenger, Christina, Dunlop, Elaine A. ORCID: https://orcid.org/0000-0002-9209-7561, Elmslie, Frances V., Girodengo, Marie, Hambleton, Sophie, Jansen, Anna C., Johnson, Simon R., Kearley, Kelly C., Kingswood, John C., Laaniste, Liisi, Lachlan, Katherine, Latchford, Andrew, Madsen, Ralitsa R., Mansour, Sahar, Mihaylov, Simeon R., Muhammed, Louwai, Oliver, Claire, Pepper, Tom, Rawlins, Lettie E., Schim van der Loeff, Ina, Siddiqui, Ata, Takhar, Pooja, Tatton-Brown, Katrina, Tee, Andrew R. ORCID: https://orcid.org/0000-0002-5577-4631, Tibarewal, Priyanka, Tye, Charlotte, Ultanir, Sila K., Vanhaesebroeck, Bart, Zare, Benjamin, Pal, Deb K. and Bateman, Joseph M. 2025. mTOR pathway diseases: challenges and opportunities from bench to bedside and the mTOR node. Orphanet Journal of Rare Diseases 20 (256) 10.1186/s13023-025-03740-1
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Bhaoighill, Muireann Ní, Falcón-Pérez, Juan M., Royo, Félix, Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631, Webber, Jason ORCID: https://orcid.org/0000-0003-4772-3014 and Dunlop, Elaine ORCID: https://orcid.org/0000-0002-9209-7561 2023. Tuberous Sclerosis Complex cell-derived EVs have an altered protein cargo capable of regulating their microenvironment and have potential as disease biomarkers. Journal of Extracellular Vesicles 12 (6) , 12336. 10.1002/jev2.12336
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Klionsky, Daniel J., Abdel-Aziz, Amal Kamal, Abdelfatah, Sara, Abdellatif, Mahmoud, Abdoli, Asghar, Abel, Steffen and Dunlop, Elaine ORCID: https://orcid.org/0000-0002-9209-7561 2021. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy 17 (1) , pp. 1-382. 10.1080/15548627.2020.1797280

Ni Bhaoighill, Muireann and Dunlop, Elaine A. ORCID: https://orcid.org/0000-0002-9209-7561 2019. Mechanistic target of rapamycin inhibitors: successes and challenges as cancer therapeutics. Cancer Drug Resistance 2019 (2) , pp. 1069-1085. 10.20517/cdr.2019.87
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Johnson, Charlotte E. ORCID: https://orcid.org/0000-0003-1954-5142, Dunlop, Elaine A. ORCID: https://orcid.org/0000-0002-9209-7561, Seifan, Sara, McCann, Henry D., Hay, Trevor, Parfitt, Geraint J. ORCID: https://orcid.org/0000-0002-8704-7906, Jones, Ashley T., Giles, Peter J. ORCID: https://orcid.org/0000-0003-3143-6854, Shen, Ming H. ORCID: https://orcid.org/0000-0002-3891-7231, Sampson, Julian R. ORCID: https://orcid.org/0000-0002-2902-2348, Errington, Rachel J. ORCID: https://orcid.org/0000-0002-8016-4376, Davies, D. Mark and Tee, Andrew R. ORCID: https://orcid.org/0000-0002-5577-4631 2018. Loss of tuberous sclerosis complex 2 sensitizes tumors to nelfinavir−bortezomib therapy to intensify endoplasmic reticulum stress-induced cell death. Oncogene 37 , pp. 5913-5925. 10.1038/s41388-018-0381-2
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McCann, Henry, Johnson, Charlotte ORCID: https://orcid.org/0000-0003-1954-5142, Errington, Rachel ORCID: https://orcid.org/0000-0002-8016-4376, Davies, D. Mark, Dunlop, Elaine ORCID: https://orcid.org/0000-0002-9209-7561 and Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 2018. Energy stress-mediated cytotoxicity in tuberous sclerosis complex 2-deficient cells with nelfinavir and mefloquine treatment. Cancers 10 (10) , 375. 10.3390/cancers10100375
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Yeung, V., Webber, J. P. ORCID: https://orcid.org/0000-0003-4772-3014, Dunlop, E. A. ORCID: https://orcid.org/0000-0002-9209-7561, Morgan, H., Hutton, J., Gurney, M. ORCID: https://orcid.org/0000-0003-1119-6638, Jones, E., Falcon-Perez, J., Tabi, Z., Errington, R. ORCID: https://orcid.org/0000-0002-8016-4376 and Clayton, A. ORCID: https://orcid.org/0000-0002-3087-9226 2018. Rab35-dependent extracellular nanovesicles are required for induction of tumour supporting stroma. Nanoscale 10 (18) , pp. 8547-8559. 10.1039/C8NR02417K
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Carroll, Bernadette and Dunlop, Elaine A. ORCID: https://orcid.org/0000-0002-9209-7561 2017. The lysosome: a crucial hub for AMPK and mTORC1 signalling. Biochemical Journal 474 (9) , pp. 1453-1466. 10.1042/BCJ20160780
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Dunlop, Elaine A ORCID: https://orcid.org/0000-0002-9209-7561, Johnson, Charlotte ORCID: https://orcid.org/0000-0003-1954-5142, Wiltshire, Marie, Errington, Rachel Jane ORCID: https://orcid.org/0000-0002-8016-4376 and Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 2017. Targeting protein homeostasis with nelfinavir/salinomycin dual therapy effectively. Oncotarget 10.18632/oncotarget.16232
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Dodd, Kayleigh M. and Dunlop, Elaine A. ORCID: https://orcid.org/0000-0002-9209-7561 2016. Tuberous sclerosis—A model for tumour growth. Seminars in Cell and Developmental Biology 52 , pp. 3-11. 10.1016/j.semcdb.2016.01.025

Carroll, Bernadette, Maetzel, Dorothea, Maddocks, Oliver D. K., Otten, Gisela, Ratcliff, Matthew, Smith, Graham R., Dunlop, Elaine A. ORCID: https://orcid.org/0000-0002-9209-7561, Passos, João F., Davies, Owen R., Jaenisch, Rudolf, Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631, Sarkar, Sovan and Korolchuk, Viktor I. 2016. Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity. eLife 5 , -. 10.7554/eLife.11058
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Dunlop, Elaine ORCID: https://orcid.org/0000-0002-9209-7561 and Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 2014. mTOR and autophagy: a dynamic relationship governed by nutrients and energy. Seminars in Cell and Developmental Biology 36 , pp. 121-129. 10.1016/j.semcdb.2014.08.006

Yan, Ming, Gingras, Marie-Claude, Dunlop, Elaine A. ORCID: https://orcid.org/0000-0002-9209-7561, Nouët, Yann, Dupuy, Fanny, Jalali, Zahra, Possik, Elite, Coull, Barry J., Kharitidi, Dmitri, Dydensborg, Anders Bondo, Faubert, Brandon, Kamps, Miriam, Sabourin, Sylvie, Preston, Rachael S., Davies, David Mark, Roughead, Taren, Chotard, Laëtitia, van Steensel, Maurice A.M., Jones, Russell, Tee, Andrew R. ORCID: https://orcid.org/0000-0002-5577-4631 and Pause, Arnim 2014. The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation. Journal of Clinical Investigation 124 (6) , pp. 2640-2650. 10.1172/JCI71749

Dunlop, Elaine ORCID: https://orcid.org/0000-0002-9209-7561, Seifan, Sara, Claessens, Tijs, Behrends, Christian, Kamps, Miriam A.F., Rozycka, Ewelina, Kemp, Alain J., Nookala, Ravi K., Blenis, John, Coull, Barry J., Murray, James T., van Steensel, Maurice A.M., Wilkinson, Simon and Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 2014. FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation. Autophagy 10 (10) , pp. 1749-1760. 10.4161/auto.29640
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Zhang, Jiangwei, Kim, Jinhee, Alexander, Angela, Cai, Shengli, Tripathi, Durga Nand, Dere, Ruhee, Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631, Tait-Mulder, Jacqueline, Di Nardo, Alessia, Han, Juliette M., Kwiatkowski, Erica, Dunlop, Elaine A. ORCID: https://orcid.org/0000-0002-9209-7561, Dodd, Kayleigh M., Folkerth, Rebecca D., Faust, Phyllis L., Kastan, Michael B., Sahin, Mustafa and Walker, Cheryl Lyn 2013. A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS. Nature Cell Biology 15 (10) , pp. 1186-1195. 10.1038/ncb2822

Thomas, Laura ORCID: https://orcid.org/0000-0002-8621-5285, Richards, Mark ORCID: https://orcid.org/0000-0002-2266-3329, Mort, Matthew Edwin, Dunlop, Elaine A. ORCID: https://orcid.org/0000-0002-9209-7561, Cooper, David Neil ORCID: https://orcid.org/0000-0002-8943-8484 and Upadhyaya, Meena 2012. Assessment of the potential pathogenicity of missense mutations identified in the GTPase-activating protein (GAP)-related domain of the neurofibromatosis type-1 (NF1) gene. Human Mutation 33 (12) , pp. 1687-1696. 10.1002/humu.22162

Dunlop, Elaine A. ORCID: https://orcid.org/0000-0002-9209-7561, Hunt, David K., Acosta-Jaquez, Hugo A., Fingar, Diane C. and Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 2011. ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding. Autophagy 7 (7) , pp. 737-747. 10.4161/auto.7.7.15491

Preston, Rachael S., Philp, A., Claessens, T., Gijezen, L., Dydensborg, A. B., Dunlop, Elaine A. ORCID: https://orcid.org/0000-0002-9209-7561, Harper, Katy T., Brinkhuizen, T., Menko, F. H., Davies, David Mark, Land, S. C., Pause, A., Baar, K., van Steensel, M. A. M. and Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 2011. Absence of the Birt-Hogg-Dubé gene product is associated with increased hypoxia-inducible factor transcriptional activity and a loss of metabolic flexibility. Oncogene 30 (10) , pp. 1159-1173. 10.1038/onc.2010.497

Dunlop, Elaine A. ORCID: https://orcid.org/0000-0002-9209-7561, Dodd, Kayleigh M., Land, Stephen C, Davies, Peter A., Martins, Nicole, Stuart, Helen, McKee, Shane, Kingswood, Chris, Saggar, Anand, Corderio, Isabel, Medeira, Ana Maria Duarte, Kingston, Helen, Sampson, Julian Roy ORCID: https://orcid.org/0000-0002-2902-2348, Davies, David Mark and Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 2011. Determining the pathogenicity of patient-derived TSC2 mutations by functional characterization and clinical evidence. European Journal of Human Genetics 19 (7) , pp. 789-795. 10.1038/ejhg.2011.38

Shi, Zhanzhong., Hodges, Vivien M., Dunlop, Elaine A. ORCID: https://orcid.org/0000-0002-9209-7561, Percy, Melanie J., Maxwell, Alexander P., El-Tanani, Mohamed. and Lappin, Terry R. J. 2010. Erythropoietin-induced activation of the JAK2/STAT5, PI3K/Akt, and Ras/ERK pathways promotes malignant cell behavior in a modified breast cancer cell line. Molecular Cancer Research 8 (4) , pp. 615-626. 10.1158/1541-7786.MCR-09-0264

Soliman, G. A., Acosta-Jaquez, H. A., Dunlop, Elaine A. ORCID: https://orcid.org/0000-0002-9209-7561, Ekim, B., Maj, N. E., Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 and Fingar, D. C. 2010. mTOR Ser-2481 Autophosphorylation Monitors mTORC-specific Catalytic Activity and Clarifies Rapamycin Mechanism of Action. Journal of Biological Chemistry 285 (11) , pp. 7866-7879. 10.1074/jbc.M109.096222

Dunlop, Elaine A. ORCID: https://orcid.org/0000-0002-9209-7561, Dodd, Kayleigh M., Seymour, Lyndsey A. and Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 2009. Mammalian target of rapamycin complex 1-mediated phosphorylation of eukaryotic initiation factor 4E-binding protein 1 requires multiple protein-protein interactions for substrate recognition. Cellular Signalling 21 (7) , pp. 1073-1084. 10.1016/j.cellsig.2009.02.024

Dunlop, Elaine A. ORCID: https://orcid.org/0000-0002-9209-7561 and Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 2009. Mammalian target of rapamycin complex 1: Signalling inputs, substrates and feedback mechanisms. Cellular Signalling 21 (6) , pp. 827-835. 10.1016/j.cellsig.2009.01.012

Dunlop, Elaine A. ORCID: https://orcid.org/0000-0002-9209-7561, Maxwell, Alexander P. and Lappin, Terence R. J. 2007. Impaired downregulation following erythropoietin receptor activation in non-small cell lung carcinoma. Stem Cells 25 (2) , pp. 380-384. 10.1634/stemcells.2006-0452

Dunlop, Elaine A. ORCID: https://orcid.org/0000-0002-9209-7561, Percy, M. J., Boland, M. P., Maxwell, A. P. and Lappin, T. R. 2006. Induction of signalling in non-erythroid cells by pharmacological levels of erythropoietin. Neurodegenerative Diseases 3 (1-2) , pp. 94-100. 10.1159/000092099

Brown, W. Mark, Maxwell, Perry, Graham, Alastair N. j., Yakkundi, Anita, Dunlop, Elaine A. ORCID: https://orcid.org/0000-0002-9209-7561, Shi, Zhanzhong, Johnston, Patrick G. and Lappin, Terence R. J. 2006. Erythropoietin receptor expression in non-Small cell lung carcinoma: a question of antibody specificity. Stem Cells 25 (3) , pp. 718-722. 10.1634/stemcells.2006-0687

This list was generated on Sat Nov 8 11:30:06 2025 GMT.


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