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Vitamin D3 suppresses morphological evolution of the cribriform cancerous phenotype.
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Deuker, Marian M., Marsh Durban, Victoria ORCID: https://orcid.org/0000-0003-1645-1618, Phillips, Wayne A. and McMahon, Martin
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PI3'-kinase inhibition forestalls the onset of MEK1/2 inhibitor resistance in BRAF-mutated melanoma.
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PTEN loss and KRAS activation leads to the formation of serrated adenomas and metastatic carcinoma in the mouse intestine.
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Epithelial-specific loss of PTEN results in colorectal juvenile polyp formation and invasive cancer.
American Journal of Pathology
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Marsh Durban, Victoria ORCID: https://orcid.org/0000-0003-1645-1618, Deuker, Marian M., Bosenberg, Marcus W., Phillips, Wayne and McMahon, Martin
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Differential AKT dependency displayed by mouse models of BRAFV600E-initiated melanoma.
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Trejo, C. L., Green, S., Marsh Durban, Victoria ORCID: https://orcid.org/0000-0003-1645-1618, Collisson, E. A., Iezza, G., Phillips, W. A. and McMahon, M.
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Mutationally activated PIK3CAH1047R cooperates with BRAFV600E to promote lung cancer progression.
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PTEN loss and KRAS activation cooperate in murine biliary tract malignancies.
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Origin and maintenance of the intestinal cancer stem cell.
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Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.
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Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation.
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Intestinal homeostasis and neoplasia studied using conditional transgenesis.
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Sansom, Owen J. ORCID: https://orcid.org/0000-0001-9540-3010, Meniel, Valerie, Wilkins, Julie Ann, Cole, Alicia M., Oien, Karin A., Marsh Durban, Victoria ORCID: https://orcid.org/0000-0003-1645-1618, Jamieson, Thomas J., Guerra, Carmen, Ashton, Gabrielle H., Barbacid, Mariano and Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X
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Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo.
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