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Number of items: 30.

Badder, Luned, Davies, James ORCID: https://orcid.org/0000-0003-3569-4500, Meniel, Valerie, Maruskova, Mahulena, Salvador, Beatriz, Bayliss, Rebecca ORCID: https://orcid.org/0000-0002-3324-957X, Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916, Hogan, Catherine ORCID: https://orcid.org/0000-0002-1012-0896 and Parker, Alan ORCID: https://orcid.org/0000-0002-9302-1761 2024. The αvβ6 integrin specific virotherapy, Ad5NULL-A20.FCU1, selectively delivers 2 potent “in-tumour” chemotherapy to Pancreatic Ductal Adenocarcinoma. British Journal of Cancer 131 , pp. 1694-1706. 10.1038/s41416-024-02869-3
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Turnham, Daniel J. ORCID: https://orcid.org/0000-0002-2540-7363, Mullen, Manisha S., Bullock, Nicholas P., Gilroy, Kathryn L., Richards, Anna E., Patel, Radhika, Quintela, Marcos, Meniel, Valerie S., Seaton, Gillian, Kynaston, Howard ORCID: https://orcid.org/0000-0003-1902-9930, Clarkson, Richard W. E. ORCID: https://orcid.org/0000-0001-7389-8673, Phesse, Toby J. ORCID: https://orcid.org/0000-0001-9568-4916, Nelson, Peter S., Haffner, Michael C., Staffurth, John N. ORCID: https://orcid.org/0000-0002-7834-3172 and Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843 2024. Development and characterisation of a new patient-derived Xenograft model of AR-negative metastatic asctration-resistant prostate cancer. Cells 13 (8) , 673. 10.3390/cells13080673
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Bates, Emily A., Davies, James A. ORCID: https://orcid.org/0000-0003-3569-4500, Vánová, Jana, Nestic, Davor, Meniel, Valerie S., Koushyar, Sarah, Cunliffe, Tabitha G., Mundy, Rosie M., Moses, Elise, Uusi-Kerttula, Hanni K., Baker, Alexander T. ORCID: https://orcid.org/0000-0001-8232-0531, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Majhen, Dragomira, Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916, Chester, John D. ORCID: https://orcid.org/0000-0002-7830-3840 and Parker, Alan L. ORCID: https://orcid.org/0000-0002-9302-1761 2022. Development of a low seroprevalence, αvβ6 integrin selective virotherapy based on human adenovirus type 10. Molecular Therapy - Oncolytics 25 , pp. 43-56. 10.1016/j.omto.2022.03.007
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Koushyar, Sarah, Meniel, Valerie S., Phesse, Toby J. ORCID: https://orcid.org/0000-0001-9568-4916 and Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843 2022. Exploring the Wnt pathway as a therapeutic target for prostate cancer. Biomolecules 12 (2) , 309. 10.3390/biom12020309
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Flanagan, Dustin J., Barker, Nick, Di Costanzo, Natasha S., Mason, Elizabeth A., Gurney, Austin, Meniel, Valerie S., Koushyar, Sarah, Austin, Chloe R., Ernst, Matthias, Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843, Boussioutas, Alex, Clevers, Hans, Phesse, Toby J. ORCID: https://orcid.org/0000-0001-9568-4916 and Vincan, Elizabeth 2019. Frizzled-7 is required for Wnt signaling in gastric tumours with and without Apc mutations. Cancer Research 79 (5) , pp. 970-981. 10.1158/0008-5472.CAN-18-2095
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Pearson, Helen B. ORCID: https://orcid.org/0000-0002-3284-0843, Li, Jason, Meniel, Valerie S., Fennell, Christina M., Waring, Paul, Montgomery, Karen G., Rebello, Richard J., Macpherson, Arthi A., Koushyar, Sarah, Furic, Luc, Cullinane, Carleen, Clarkson, Richard W. ORCID: https://orcid.org/0000-0001-7389-8673, Smalley, Matthew J. ORCID: https://orcid.org/0000-0001-9540-1146, Simpson, Kaylene J., Phesse, Toby J. ORCID: https://orcid.org/0000-0001-9568-4916, Shepherd, Peter R., Humbert, Patrick O., Sansom, Owen J. and Phillips, Wayne A. 2018. Identification of Pik3ca mutation as a genetic driver of prostate cancer that cooperates with Pten loss to accelerate progression and castration-resistant growth. Cancer Discovery 8 (6) , pp. 764-779. 10.1158/2159-8290.CD-17-0867
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Burke, Zoe D., Reed, Karen Ruth ORCID: https://orcid.org/0000-0002-7467-1718, Yeh, Sheng-Wen, Meniel, Valerie S., Sansom, Owen J., Clarke, Alan R. and Tosh, David 2018. Spatiotemporal regulation of liver development by the Wnt/β- catenin pathway. Scientific Reports 8 , 2735. 10.1038/s41598-018-20888-y
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Jefferies, Matthew T., Cox, Adam C., Shorning, Boris Y., Meniel, Valerie, Griffiths, David, Kynaston, Howard G. ORCID: https://orcid.org/0000-0003-1902-9930, Smalley, Matthew J. ORCID: https://orcid.org/0000-0001-9540-1146 and Clarke, Alan R. 2017. PTEN loss and activation of K-RAS and β-catenin cooperate to accelerate prostate tumourigenesis. Journal of Pathology 243 (4) , pp. 442-456. 10.1002/path.4977
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Berenjeno, Inma M., Piñeiro, Roberto, Castillo, Sandra D., Pearce, Wayne, McGranahan, Nicholas, Dewhurst, Sally M., Meniel, Valerie, Birkbak, Nicolai J., Lau, Evelyn, Sansregret, Laurent, Morelli, Daniele, Kanu, Nnennaya, Srinivas, Shankar, Graupera, Mariona, Parker, Victoria E. R., Montgomery, Karen G., Moniz, Larissa S., Scudamore, Cheryl L., Phillips, Wayne A., Semple, Robert K., Clarke, Alan, Swanton, Charles and Vanhaesebroeck, Bart 2017. Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling. Nature Communications 8 (1) , 1773. 10.1038/s41467-017-02002-4
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Soady, Kelly J., Tornillo, Giusy, Kendrick, Howard, Meniel, Valerie, Olijnyk-Dallis, Daria, Morris, Joanna S., Stein, Torstein, Gusterson, Barry A., Isacke, Clare M. and Smalley, Matthew J. ORCID: https://orcid.org/0000-0001-9540-1146 2017. Receptor protein tyrosine phosphatase PTPRB negatively regulates FGF2-dependent branching morphogenesis. Development 144 (20) , pp. 3777-3788. 10.1242/dev.149120
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Naschberger, Elisabeth, Liebl, Andrea, Schellerer, Vera S., Schütz, Manuela, Britzen-Laurent, Nathalie, Kölbel, Patrick, Schaal, Ute, Haep, Lisa, Regensburger, Daniela, Wittmann, Thomas, Klein-Hitpass, Ludger, Rau, Tilman T., Dietel, Barbara, Meniel, Valerie, Clarke, Alan R., Merkel, Susanne, Croner, Roland S., Hohenberger, Werner and Stürzl, Michael 2016. Matricellular protein SPARCL1 regulates tumor microenvironment-dependent endothelial cell heterogeneity in colorectal carcinoma. The Journal of Clinical Investigation 126 (11) , pp. 4187-4204. 10.1172/JCI78260

Huels, David J., Ridgway, Rachel A., Radulescu, Sorina, Leushacke, Marc, Campbell, Andrew D., Biswas, Sujata, Leedham, Simon, Serra, Stefano, Chetty, Runjan, Moreaux, Guenievre, Parry, Lee ORCID: https://orcid.org/0000-0002-4467-9196, Matthews, James, Song, Fei, Hedley, Ann, Kalna, Gabriela, Ceteci, Fatih, Reed, Karen R. ORCID: https://orcid.org/0000-0002-7467-1718, Meniel, Valerie S., Maguire, Aoife, Doyle, Brendan, Soderberg, Ola, Barker, Nick, Watson, Alastair, Larue, Lionel, Clarke, Alan R. ORCID: https://orcid.org/0000-0002-4281-426X and Sansom, Owen J. 2015. E-cadherin can limit the transforming properties of activating β‐catenin mutations. EMBO Journal 34 (18) , pp. 2321-2333. 10.15252/embj.201591739
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Meniel, Valerie, Megges, M., Young, Madeleine, Cole, A., Sansom, O. J. and Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X 2015. Apc and p53 interaction in DNA damage and genomic instability in hepatocytes. Oncogene 34 , pp. 4118-4129. 10.1038/onc.2014.342

Reed, Karen Ruth ORCID: https://orcid.org/0000-0002-7467-1718, Athineos, Dimitris, Meniel, Valerie, Wilkins, Julie A., Ridgway, Rachel A., Burke, Zoe D., Muncan, Vanessa, Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X and Sansom, Owen J. 2015. Correction for Reed et al., B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver. Proceedings of the National Academy of Sciences of the United States of America 112 (10) , E1168. 10.1073/pnas.1502294112

Davies, Emma Jane, Marsh Durban, Victoria ORCID: https://orcid.org/0000-0003-1645-1618, Meniel, Valerie, Williams, Geraint Trfor ORCID: https://orcid.org/0000-0003-3768-9940 and Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X 2014. PTEN loss and KRAS activation leads to the formation of serrated adenomas and metastatic carcinoma in the mouse intestine. The Journal of Pathology 233 (1) , pp. 27-38. 10.1002/path.4312

Hammoudi, Abeer, Song, Fei, Reed, Karen Ruth ORCID: https://orcid.org/0000-0002-7467-1718, Jenkins, Rosalind E., Meniel, Valerie, Watson, Alastair J. M., Pritchard, D. Mark, Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X and Jenkins, John R. 2013. Proteomic profiling of a mouse model of acute intestinal Apc deletion leads to identification of potential novel biomarkers of human colorectal cancer (CRC). Biochemical and Biophysical Research Communications 440 (3) , pp. 364-370. 10.1016/j.bbrc.2013.08.076

Meniel, Valerie, Song, Fei, Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916, Young, Madeleine, Poetz, Oliver, Parry, Lee ORCID: https://orcid.org/0000-0002-4467-9196, Jenkins, John R., Williams, Geraint Trefor ORCID: https://orcid.org/0000-0003-3768-9940, Dunwoodie, Sally L., Watson, Alastair and Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X 2013. Cited1 deficiency suppresses intestinal tumorigenesis. PLoS Genetics 9 (8) , e1003638. 10.1371/journal.pgen.1003638
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Feng, Gui Jie, Cotta, Welwyn, Wei, Xiao-Qing ORCID: https://orcid.org/0000-0002-6274-8503, Poetz, Oliver, Evans, Rebecca Jane, Jardé, Thierry, Reed, Karen Ruth ORCID: https://orcid.org/0000-0002-7467-1718, Meniel, Valerie, Williams, Geraint Trefor ORCID: https://orcid.org/0000-0003-3768-9940, Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X and Dale, Trevor Clive ORCID: https://orcid.org/0000-0002-4880-9963 2012. Conditional disruption of Axin1 leads to development of liver tumors in mice. Gastroenterology 143 (6) , pp. 1650-1659. 10.1053/j.gastro.2012.08.047

Buchert, Michael, Athineos, Dimitris, Abud, Helen E., Burke, Zoe D., Faux, Maree C., Samuel, Michael S., Jarnicki, Andrew G., Winbanks, Catherine E., Newton, Ian P, Meniel, Valerie, Suzuki, Hiromu, Stacker, Steven A., Näthke, Inke S., Tosh, David, Huelsken, Joerg, Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X, Heath, Joan K., Sansom, Owen J. ORCID: https://orcid.org/0000-0001-9540-3010 and Ernst, Matthias 2010. Genetic dissection of differential signaling threshold requirements for the Wnt/beta-Catenin pathway in vivo. PLOS Genetics 6 (1) , e1000816. 10.1371/journal.pgen.1000816
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Reed, Karen Ruth ORCID: https://orcid.org/0000-0002-7467-1718, Athineos, Dimitris, Meniel, Valerie, Wilkins, Julie Ann, Ridgeway, Rachel A., Burke, Zoe D., Muncan, Vanesa, Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X and Sansom, Owen J. ORCID: https://orcid.org/0000-0001-9540-3010 2008. B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver. Proceedings of the National Academy of Sciences of the United States of America 105 (48) , pp. 18919-18923. 10.1073/pnas.0805778105

Reed, Karen Ruth ORCID: https://orcid.org/0000-0002-7467-1718, Meniel, Valerie, Marsh Durban, Victoria ORCID: https://orcid.org/0000-0003-1645-1618, Cole, Alicia, Sansom, Owen J. ORCID: https://orcid.org/0000-0001-9540-3010 and Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X 2008. A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine. BMC Cancer 8 , 162. 10.1186/1471-2407-8-162
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Sansom, Owen J. ORCID: https://orcid.org/0000-0001-9540-3010, Meniel, Valerie, Muncan, Vanesa, Phesse, Toby ORCID: https://orcid.org/0000-0001-9568-4916, Wilkins, Julie Ann, Reed, Karen Ruth ORCID: https://orcid.org/0000-0002-7467-1718, Vass, Keith, Athineos, Dimitris, Clevers, Hans and Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X 2007. Myc deletion rescues Apc deficiency in the small intestine. Nature 446 (7136) , pp. 676-679. 10.1038/nature05674

Dikovskaya, Dina, Schiffmann, David, Newton, Ian P., Oakley, Abigail, Kroboth, Karin, Sansom, Owen J. ORCID: https://orcid.org/0000-0001-9540-3010, Jamieson, Thomas J., Meniel, Valerie, Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X and Nathke, Inke S. 2007. Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis. Journal of cell biology 176 (2) , pp. 183-195. 10.1083/jcb.200610099

Dikovskaya, Dina, Schiffmann, David, Newton, Ian P., Oakley, Abigail, Kroboth, Karin, Sansom, Owen J. ORCID: https://orcid.org/0000-0001-9540-3010, Jamieson, Thomas J., Meniel, Valerie, Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X and Nathke, Inke S. 2007. Correction 176, p. 183. Journal of cell biology 176 (3) , p. 369. 10.1083/jcb.20061009920070116c

Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X and Meniel, Valerie 2007. The intestinal stem cell niche studied through conditional transgenesis. Presented at: The Cancer Stem Cell Workshop, Berlin, Germany, November 15- 17 2006. Published in: Wiestler, O. D., Haendler, B. and Mumberg, D. eds. Cancer Stem Cells: Novel Concepts and Prospects for Tumor Therapy. Cancer Stem Cells: Novel Concepts and Prospects for Tumor Therapy. Ernst Schering Foundation Symposium Proceedings , vol.2006/5 Berlin: Springer, pp. 99-108. 10.1007/2789_2007_046

Sansom, Owen J. ORCID: https://orcid.org/0000-0001-9540-3010, Meniel, Valerie, Wilkins, Julie Ann, Cole, Alicia M., Oien, Karin A., Marsh Durban, Victoria ORCID: https://orcid.org/0000-0003-1645-1618, Jamieson, Thomas J., Guerra, Carmen, Ashton, Gabrielle H., Barbacid, Mariano and Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X 2006. Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo. Proceedings of the National Academy of Sciences 103 (38) , pp. 14122-14127. 10.1073/pnas.0604130103

Meniel, Valerie, Hay, Trevor, Douglas-Jones, Anthony Gordon, Sansom, Owen J. ORCID: https://orcid.org/0000-0001-9540-3010 and Clarke, Alan R. ORCID: https://orcid.org/0000-0002-4281-426X 2005. Mutations in Apc and p53 synergize to promote mammary neoplasia. Cancer Research 65 (24) , pp. 410-6.

Meniel, Valerie and Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X 2003. Wnt-Cadherin connections in normal and neoplastic mammary epithelium. Journal of Mammary Gland Biology and Neoplasia 8 (4) , pp. 435-447. 10.1023/B:JOMG.0000017430.12210.37

Gallagher, Ronald C. J., Hay, Trevor, Meniel, Valerie, Naughton, Catherine, Anderson, Thomas J., Shibata, Hiroyuki, Ito, Masaki, Clevers, Hans, Noda, Tetsuo, Sansom, Owen J. ORCID: https://orcid.org/0000-0001-9540-3010, Mason, John O. and Clarke, Alan Richard ORCID: https://orcid.org/0000-0002-4281-426X 2002. Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency. Oncogene 21 (42) , pp. 6446-6457. 10.1038/sj.onc.1205892

Morse, Nerys R., Meniel, Valerie and Waters, Raymond 2002. Photoreactivation of UV-induced cyclobutane primidine dimers in the MFA2 gene of S. cerevisiae. Nucleic Acids Research 30 (8) , pp. 1799-1807. 10.1093/nar/30.8.1799

This list was generated on Thu Oct 23 12:25:48 2025 BST.


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