Longhi, Maria Paula, Wright, Kate Louise, Lauder, Sarah Nicol, Nowell, Mari Ann, Jones, Gareth Wyn, Godkin, Andrew James  ORCID: https://orcid.org/0000-0002-1910-7567, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004
2008.
Interleukin-6 is crucial for recall of influenza-specific memory cd4+ t cells.
PLoS Pathogens
4
(2)
, e1000006.
10.1371/journal.ppat.1000006
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Abstract
Currently, our understanding of mechanisms underlying cell-mediated immunity and particularly of mechanisms that promote robust T cell memory to respiratory viruses is incomplete. Interleukin (IL)-6 has recently re-emerged as an important regulator of T cell proliferation and survival. Since IL-6 is abundant following infection with influenza virus, we analyzed virus-specific T cell activity in both wild type and IL-6 deficient mice. Studies outlined herein highlight a novel role for IL-6 in the development of T cell memory to influenza virus. Specifically, we find that CD4+ but not CD8+ T cell memory is critically dependent upon IL-6. This effect of IL-6 includes its ability to suppress CD4+CD25+ regulatory T cells (Treg). We demonstrate that influenza-induced IL-6 limits the activity of virus-specific Tregs, thereby facilitating the activity of virus-specific memory CD4+ T cells. These experiments reveal a critical role for IL-6 in ensuring, within the timeframe of an acute infection with a cytopathic virus, that antigen-specific Tregs have no opportunity to down-modulate the immune response, thereby favoring pathogen clearance and survival of the host.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine Research Institutes & Centres > Systems Immunity Research Institute (SIURI) |
| Subjects: | Q Science > QR Microbiology > QR180 Immunology R Medicine > R Medicine (General) |
| Publisher: | Public Library of Science |
| ISSN: | 1553-7374 |
| Funders: | MRC Senior Fellowship (G117/488), Wellcome Trust (080340) |
| Date of First Compliant Deposit: | 30 March 2016 |
| Last Modified: | 05 Feb 2025 22:34 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/28776 |
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