Millrine, David, Cardus Figueras, Ana, Uceda Fernandez, Javier, Andrews, Robert, Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Cossins, Benjamin, Rice, Christopher M., Li, Jasmine, Tyrrell, Victoria, McLeod, Louise, Holmans, Peter ORCID: https://orcid.org/0000-0003-0870-9412, O'Donnell, Valerie ORCID: https://orcid.org/0000-0003-4089-8460, Taylor, Philip ORCID: https://orcid.org/0000-0003-0163-1421, Turner, Stephen J., Jenkins, Brendan J., Jones, Gareth, Topley, Nicholas, Williams, Nigel ORCID: https://orcid.org/0000-0003-1177-6931 and Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711 2023. Th1 cells alter the inflammatory signature of IL-6 by channeling STAT transcription factors to Alu-like retroelements. The Journal of Immunology 211 (2) , pp. 274-286. 10.4049/jimmunol.2300114 |
Davies, Ruth, Williams, Jessica, Sime, Katie, Jin, Hyun-Sun, Thompson, Charlotte, Jordan, Lauren, Lang, Derek, Halcox, Julian P, Ellins, Elizabeth ORCID: https://orcid.org/0000-0001-5164-6416, Jones, Gareth, Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711, Rose-John, Stefan, Williams, Anwen ORCID: https://orcid.org/0000-0001-6118-020X and Choy, Ernest ORCID: https://orcid.org/0000-0003-4459-8609 2021. The role of interleukin-6 trans-signalling on cardiovascular dysfunction in inflammatory arthritis. Rheumatology 60 (6) , pp. 2852-2861. 10.1093/rheumatology/keaa725 |
Harbour, Stacey N., DiToro, Daniel F., Witte, Steven J., Zindl, Carlene L., Gao, Min, Schoeb, Trenton R., Jones, Gareth W., Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711, Hatton, Robin D. and Weaver, Casey T. 2020. Th17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity. Science Immunology 5 (49) , eaaw2262. 10.1126/sciimmunol.aaw2262 |
Thompson, Charlotte, Davies, Ruth, Williams, Anwen ORCID: https://orcid.org/0000-0001-6118-020X, Jones, Gareth and Choy, Ernest H. S. ORCID: https://orcid.org/0000-0003-4459-8609 2020. CD28− Cells are increased in early rheumatoid arthritis and are linked with cytomegalovirus status. Frontiers in Medicine 7 , 129. 10.3389/fmed.2020.00129 |
Wiede, Florian, Brodnicki, Thomas C., Goh, Pei Kee, Leong, Yew A., Jones, Gareth W., Yu, Di, Baxter, Alan G., Jones, Simon A., Kay, Thomas W. H. and Tiganis, Tony 2019. T-cell–specific PTPN2 deficiency in NOD mice accelerates the development of type 1 diabetes and autoimmune comorbidities. Diabetes 68 (6) , pp. 1251-1266. 10.2337/db18-1362 |
Twohig, Jason P., Cardus Figueras, Ana, Andrews, Robert, Wiede, Florian, Cossins, Benjamin C., Derrac Soria, Alicia, Lewis, Myles J., Townsend, Michael J., Millrine, David ORCID: https://orcid.org/0000-0002-8041-0151, Li, Jasmine, Hill, David G., Uceda Fernandez, Javier, Liu, Xiao, Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Pepper, Christopher J., Taylor, Philip R. ORCID: https://orcid.org/0000-0003-0163-1421, Pitzalis, Costantino, Tiganis, Tony, Williams, Nigel M. ORCID: https://orcid.org/0000-0003-1177-6931, Jones, Gareth W. and Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711 2019. Activation of naïve CD4+ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4+ T cells. Nature Immunology 20 , pp. 458-470. 10.1038/s41590-019-0350-0 |
Rivellese, Felice, Mauro, Daniele, Nerviani, Alessandra, Pagani, Sara, Fossati-Jimack, Liliane, Messemaker, Tobias, Kurreeman, Fina, Toes, Rene, Rauber, Simon, Schett, Georg, Jones, Gareth, Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711, Rossi, Francesca, de Paulis, Amato, Marone, Gianni, El Shikh, Mohey Eldin and Humby, Frances 2018. Mast cells in early rheumatoid arthritis associate with disease severity and support B-cell autoantibody production. Annals of the Rheumatic Diseases 77 (12) , pp. 1773-1781. 10.1136/annrheumdis-2018-213418 |
Hill, David, Yu, Liang, Gao, Hugh, Balic, Jesse J., West, Alison, Oshima, Hiroko, McLeod, Louise, Oshima, Masanobu, Gallimore, Awen M. ORCID: https://orcid.org/0000-0001-6675-7004, D'Costa, Kimberley, Bhathal, Prithi S., Sievert, William, Ferrero, Richard L., Jenkins, Brendan J. and Jones, Gareth W. 2018. Hyperactive gp130/STAT3-driven gastric tumourigenesis promotes submucosal tertiary lymphoid structure development. International Journal of Cancer 143 (1) , pp. 167-178. 10.1002/ijc.31298 |
Jones, Gareth, Hill, David, Cardus Figueras, Ana and Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711 2018. IL-27 - a double agent in the IL-6 family. Clinical and Experimental Immunology 193 (1) , pp. 37-46. 10.1111/cei.13116 |
Jones, Gareth, Hill, David, Sime, Katie and Williams, Anwen ORCID: https://orcid.org/0000-0001-6118-020X 2018. In Vivo models for inflammatory arthritis. Jenkins, B, ed. Inflammation and Cancer. Methods in Molecular Biology, Vol. 1725. Methods in Molecular Biology, New York, NY: Humana Press, pp. 101-118. (10.1007/978-1-4939-7568-6_9) |
Colbeck, Emily Jayne, Ager, Ann, Gallimore, Awen ORCID: https://orcid.org/0000-0001-6675-7004 and Jones, Gareth Wyn 2017. Tertiary lymphoid structures in cancer: drivers of antitumor immunity, immunosuppression, or bystander sentinels in disease? Frontiers in Immunology 8 , 1830. 10.3389/fimmu.2017.01830 |
Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Marsden, Morgan, Stacey, Maria, Abdul-Karim, Juneid, Gimeno Brias, Silvia, Costa Bento, Diana Filipa, Scurr, Martin ORCID: https://orcid.org/0000-0002-4120-0688, Weaver, Casey, Carlesso, Gianluca, Clare, Simon, Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711, Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567, Ghazal, Peter ORCID: https://orcid.org/0000-0003-0035-2228, Jones, Gareth W. and Humphreys, Ian ORCID: https://orcid.org/0000-0002-9512-5337 2016. Cytomegalovirus-specific IL-10-producing CD4+ T cells are governed by type-I IFN-induced IL-27 and promote virus persistence. Plos Pathogens 12 (12) , e1006050. 10.1371/journal.ppat.1006050 |
Jones, Gareth, Hill, David and Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711 2016. Understanding immune cells in tertiary lymphoid organ development: it is all starting to come together. Frontiers in Immunology 7 , pp. 1-13. 10.3389/fimmu.2016.00401 |
Patin, Emmanuel, Jones, Adam V., Thompson, Aiysha, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Liao, Chia-Te, Griffiths, James S., Wallace, Leah, Bryant, Clare E., Lang, Roland, Rosenstiel, Philip, Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, Jones, Gareth Wyn and Orr, Selinda Jane 2016. IL-27 induced by Select Candida spp. via TLR7/NOD2 signaling and IFN-β production inhibits fungal clearance. The Journal of Immunology 197 (1) , pp. 208-221. 10.4049/jimmunol.1501204 |
Liu, Xiang, Jones, Gareth W., Choy, Ernest H. ORCID: https://orcid.org/0000-0003-4459-8609 and Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711 2016. The biology behind interleukin-6 targeted interventions. Current Opinion in Rheumatology 28 (2) , pp. 152-160. 10.1097/BOR.0000000000000255 |
Lacroix, Marine, Rousseau, François, Guilhot, Florence, Malinge, Pauline, Magistrelli, Giovanni, Herren, Suzanne, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Jones, Gareth Wyn, Scheller, Jürgen, Lissilaa, Rami, Kosco-Vilbois, Marie, Johnson, Zoë, Buatois, Vanessa and Ferlin, Walter 2015. Novel insights into IL-6 cis- and trans-signaling pathways by differentially manipulating the assembly of the IL-6 signaling complex. Journal of Biological Chemistry 290 , pp. 26943-26953. 10.1074/jbc.M115.682138 |
Jones, Gareth W., Bombardieri, Michele, Greenhill, Claire J., McLeod, Louise, Nerviani, Alessandra, Rocher-Ros, Vidalba, Cardus, Anna, Williams, Anwen S. ORCID: https://orcid.org/0000-0001-6118-020X, Pitzalis, Costantino, Jenkins, Brendan J. and Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711 2015. Interleukin-27 inhibits ectopic lymphoid-like structure development in early inflammatory arthritis. Journal of Experimental Medicine 212 (11) , pp. 1793-1802. 10.1084/jem.20132307 |
Jones, Gareth Wyn, McLeod, Louise, Kennedy, Catherine L., Bozinovski, Steven, Najdovska, Meri and Jenkins, Brendan J. 2015. Imbalanced gp130 signalling in ApoE-deficient mice protects against atherosclerosis. Atherosclerosis 238 (2) , pp. 321-328. 10.1016/j.atherosclerosis.2014.12.037 |
Greenhill, Claire J., Jones, Gareth Wyn, Nowell, Mari Ann, Newton, Zarabeth, Harvey, Ann K., Moideen, Abdul Nazeer, Collins, Fraser L., Bloom, Anja C., Coll, Rebecca C., Robertson, Avril A. B., Cooper, Matthew A., Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, O'Neill, Luke A., Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2014. Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction. Arthritis Research and Therapy 16 (4) , 419. 10.1186/s13075-014-0419-y |
Pitzalis, Costantino, Jones, Gareth Wyn, Bombardieri, Michele and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2014. Ectopic lymphoid-like structures in infection, cancer and autoimmunity. Nature Reviews Immunology 14 (7) , pp. 447-462. 10.1038/nri3700 |
Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Fraser, Donald James ORCID: https://orcid.org/0000-0003-0102-9342, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153 and Jones, Gareth Wyn 2014. Interleukin-6 in renal disease and therapy. Nephrology Dialysis Transplantation 30 (4) , pp. 564-574. 10.1093/ndt/gfu233 |
Jones, Gareth Wyn, Greenhill, C. J., Williams, J. O., Nowell, Mari Ann, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Jenkins, B. J. and Jones, S. A. 2013. Exacerbated inflammatory arthritis in response to hyperactive gp130 signalling is independent of IL-17A. Annals of the Rheumatic Diseases 72 (10) , pp. 1738-1742. 10.1136/annrheumdis-2013-203771 |
Greenhill, Claire J., Jones, Gareth Wyn, Nowell, Mari Ann, Harvey, Ann, Moideen, Abdul Nazeer, Collins, Fraser, Bloom, Anja Constanze, Coll, R., Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, O'Neill, L. A., Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2013. Interleukin 10 control of the inflammasome restricts arthritic bone erosion [Abstract]. Cytokine 63 (3) , p. 267. 10.1016/j.cyto.2013.06.105 |
Orr, Selinda Jane, Burg, Ashley R., Chan, Tim, Quigley, Laura, Jones, Gareth Wyn, Ford, Jill W., Hodge, Deborah, Razzook, Catherine, Sarhan, Joseph, Jones, Yava L., Whittaker, Gillian C., Boelte, Kimberly C., Lyakh, Lyudmila, Cardone, Marco, O'Connor, Geraldine M., Tan, Cuiyan, Li, Hongchuan, Anderson, Stephen K., Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Zhang, Weiguo, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, Trinchieri, Giorgio and McVicar, Daniel W. 2013. LAB/NTAL facilitates fungal/PAMP-induced IL-12 and IFN-γ production by repressing β-catenin activation in dendritic cells. PLoS Pathogens 9 (5) , e1003357. 10.1371/journal.ppat.1003357 |
Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, Heydeck, Dagmar, Jones, Gareth Wyn, Kronke, Gerhard, Funk, Colin D., Knapper, Steven ORCID: https://orcid.org/0000-0002-6405-4441, Adams, Deborah, Kuhn, Hartmut and O'Donnell, Valerie Bridget ORCID: https://orcid.org/0000-0003-4089-8460 2012. Development of myeloproliferative disease in 12/15-lipoxygenase deficiency [Letter]. Blood 119 (25) , pp. 6173-6174. 10.1182/blood-2012-02-410928 |
Jones, Gareth Wyn, Greenhill, Claire J., Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Nowell, Mari Ann, Jenkins, Brian J. and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2012. Interleukin-27 receptor-deficient mice develop exacerbated inflammatory arthritis associated with heightened T- and B-cell responses [Abstract]. Rhuematology 51 (s3) , pp. 43-44. 10.1093/rheumatology/kes117 |
Jones, Gareth Wyn, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Nowell, Mari Ann, Jenkins, Brian J. and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2011. Interleukin-27 receptor-deficient mice develop exacerbated inflammatory arthritis associated with heightened T- and B- cell responses [Abstract]. Arthritis and Rheumatism 63 (s10) , S978-S978. 10.1002/art.33310 |
Jones, Gareth Wyn, Stumhofer, Jason S., Foster, Tom, Twohig, Jason Peter, Hertzog, Paul, Topley, Nicholas, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Hunter, Christopher A., Jenkins, Brendan J., Wang, Edward Chung Yern ORCID: https://orcid.org/0000-0002-2243-4964 and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2011. Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation. The FASEB Journal 25 (1) , pp. 409-419. 10.1096/fj.10-166843 |
Kennedy, Catherine L., Najdovska, Meri, Jones, Gareth Wyn, McLeod, Louise, Hughes, Norman R., Allison, Cody, Huey Ooi, Chia, Tan, Patrick, Ferrero, Richard L., Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Dev, Anouk, Sievert, William, Bhathal, Prithi S. and Jenkins, Brendan J. 2011. The molecular pathogenesis of STAT3-driven gastric tumourigenesis in mice is independent of IL-17. The Journal of Pathology 225 (2) , pp. 255-264. 10.1002/path.2933 |
Jones, Gareth Wyn, Stumhofer, J. S., Foster, T., Twohig, Jason Peter, Hertzog, P., Topley, Nicholas, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Hunter, Catherine, Jenkins, Brian J., Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Wang, Edward Chung Yern ORCID: https://orcid.org/0000-0002-2243-4964 2010. Differential responsiveness of naive and activated T cells to TL1A that affect Th17 generation, maintenance and proliferation [Abstract]. Immunology 131 (s1) , p. 102. 10.1111/j.1365-2567.2010.03390.x |
Lissilaa, Rami, Buatois, Vanessa, Magistrelli, Giovanni, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Jones, Gareth Wyn, Herren, Suzanne, Shang, Limin, Malinge, Pauline, Guilhot, Florence, Chatel, Laurence, Hatterer, Eric, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Kosco-Vilbois, Marie H. and Ferlin, Walter G. 2010. Although IL-6 trans-signaling is sufficient to drive local immune responses, classical IL-6 signaling is obligate for the induction of T cell-mediated autoimmunity. The Journal of Immunology 185 (9) , pp. 5512-5521. 10.4049/jimmunol.1002015 |
Jones, Gareth Wyn, McLoughlin, Rachel Mary, Hammond, Victoria Jayne, Parker, Clare Rhian, Williams, John, Malhotra, Raj, Scheller, Jurgen, Williams, Anwen ORCID: https://orcid.org/0000-0001-6118-020X, Rose-John, Stefan, Topley, Nicholas and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2010. Loss of CD4+ T Cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. The Journal of Immunology 184 (4) , pp. 2130-2139. 10.4049/jimmunol.0901528 |
Jones, Gareth Wyn, McLoughlin, R. M., Hammond, Victoria Jayne, Parker, Clare R., Williams, John D., Malhotra, R., Scheller, J., Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Rose-John, Stefan, Topley, Nicholas and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2010. Loss of CD4(+) T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. Journal of Immunology 184 (4) , pp. 2130-2139. |
Nowell, Mari Ann, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Carty, Sara Madelaine, Scheller, Jurgen, Hayes, Anthony Joseph, Jones, Gareth Wyn, Richards, Peter James, Slinn, Simon James, Ernst, Matthias, Jenkins, Brendan J., Topley, Nicholas, Rose-John, Stephen and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2009. Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis. Journal of Immunology 182 (1) , pp. 613-622. |
Jones, Gareth Wyn, Stumhofer, J. S., Newton, Zarabeth, Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004, Ernst, M., Topley, Nicholas, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Hunter, Catherine, Jenkins, Brian J., Wang, Edward Chung Yern ORCID: https://orcid.org/0000-0002-2243-4964 and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2008. TL1A/TNFSF15 promotes a STAT1-mediated suppression of IL-17-secreting T-helper cells [Abstract]. Immunology 125 (s1) , p. 62. 10.1111/j.1365-2567.2008.02974.x |
Longhi, Maria Paula, Wright, Kate Louise, Lauder, Sarah Nicol, Nowell, Mari Ann, Jones, Gareth Wyn, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004 2008. Interleukin-6 is crucial for recall of influenza-specific memory cd4+ t cells. PLoS Pathogens 4 (2) , e1000006. 10.1371/journal.ppat.1000006 |
Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Jones, Gareth Wyn, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X and Nowell, Mari Ann 2008. Appreciating the balance between classical interleukin (IL)-6 receptor signaling and IL-6 trans-signaling: implications for arthritis progression. Immunology Endocrine & Metabolic Agents in Medicinal Chemistry 8 (3) , pp. 235-246. |