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Th1 cells alter the inflammatory signature of IL-6 by channeling STAT transcription factors to Alu-like retroelements.
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The role of interleukin-6 trans-signalling on cardiovascular dysfunction in inflammatory arthritis.
Rheumatology
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Harbour, Stacey N., DiToro, Daniel F., Witte, Steven J., Zindl, Carlene L., Gao, Min, Schoeb, Trenton R., Jones, Gareth W., Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711, Hatton, Robin D. and Weaver, Casey T.
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Th17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity.
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Thompson, Charlotte, Davies, Ruth, Williams, Anwen ORCID: https://orcid.org/0000-0001-6118-020X, Jones, Gareth and Choy, Ernest H. S. ORCID: https://orcid.org/0000-0003-4459-8609
2020.
CD28− Cells are increased in early rheumatoid arthritis and are linked with cytomegalovirus status.
Frontiers in Medicine
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10.3389/fmed.2020.00129
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Wiede, Florian, Brodnicki, Thomas C., Goh, Pei Kee, Leong, Yew A., Jones, Gareth W., Yu, Di, Baxter, Alan G., Jones, Simon A., Kay, Thomas W. H. and Tiganis, Tony
2019.
T-cell–specific PTPN2 deficiency in NOD mice accelerates the development of type 1 diabetes and autoimmune comorbidities.
Diabetes
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Twohig, Jason P., Cardus Figueras, Ana, Andrews, Robert, Wiede, Florian, Cossins, Benjamin C., Derrac Soria, Alicia, Lewis, Myles J., Townsend, Michael J., Millrine, David ORCID: https://orcid.org/0000-0002-8041-0151, Li, Jasmine, Hill, David G., Uceda Fernandez, Javier, Liu, Xiao, Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Pepper, Christopher J., Taylor, Philip R. ORCID: https://orcid.org/0000-0003-0163-1421, Pitzalis, Costantino, Tiganis, Tony, Williams, Nigel M. ORCID: https://orcid.org/0000-0003-1177-6931, Jones, Gareth W. and Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711
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Activation of naïve CD4+ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4+ T cells.
Nature Immunology
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Rivellese, Felice, Mauro, Daniele, Nerviani, Alessandra, Pagani, Sara, Fossati-Jimack, Liliane, Messemaker, Tobias, Kurreeman, Fina, Toes, Rene, Rauber, Simon, Schett, Georg, Jones, Gareth, Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711, Rossi, Francesca, de Paulis, Amato, Marone, Gianni, El Shikh, Mohey Eldin and Humby, Frances
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Mast cells in early rheumatoid arthritis associate with disease severity and support B-cell autoantibody production.
Annals of the Rheumatic Diseases
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10.1136/annrheumdis-2018-213418
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Jones, Gareth, Hill, David, Cardus Figueras, Ana and Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711
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IL-27 - a double agent in the IL-6 family.
Clinical and Experimental Immunology
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10.1111/cei.13116
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Hill, David, Yu, Liang, Gao, Hugh, Balic, Jesse J., West, Alison, Oshima, Hiroko, McLeod, Louise, Oshima, Masanobu, Gallimore, Awen M. ORCID: https://orcid.org/0000-0001-6675-7004, D'Costa, Kimberley, Bhathal, Prithi S., Sievert, William, Ferrero, Richard L., Jenkins, Brendan J. and Jones, Gareth W.
2018.
Hyperactive gp130/STAT3-driven gastric tumourigenesis promotes submucosal tertiary lymphoid structure development.
International Journal of Cancer
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Jones, Gareth, Hill, David, Sime, Katie and Williams, Anwen ORCID: https://orcid.org/0000-0001-6118-020X
2018.
In Vivo models for inflammatory arthritis.
Jenkins, B, ed.
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Colbeck, Emily Jayne, Ager, Ann, Gallimore, Awen ORCID: https://orcid.org/0000-0001-6675-7004 and Jones, Gareth Wyn
2017.
Tertiary lymphoid structures in cancer: drivers of antitumor immunity, immunosuppression, or bystander sentinels in disease?
Frontiers in Immunology
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, 1830.
10.3389/fimmu.2017.01830
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Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Marsden, Morgan, Stacey, Maria, Abdul-Karim, Juneid, Gimeno Brias, Silvia, Costa Bento, Diana Filipa, Scurr, Martin ORCID: https://orcid.org/0000-0002-4120-0688, Weaver, Casey, Carlesso, Gianluca, Clare, Simon, Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711, Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567, Ghazal, Peter ORCID: https://orcid.org/0000-0003-0035-2228, Jones, Gareth W. and Humphreys, Ian ORCID: https://orcid.org/0000-0002-9512-5337
2016.
Cytomegalovirus-specific IL-10-producing CD4+ T cells are governed by type-I IFN-induced IL-27 and promote virus persistence.
Plos Pathogens
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10.1371/journal.ppat.1006050
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Jones, Gareth, Hill, David and Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711
2016.
Understanding immune cells in tertiary lymphoid organ development: it is all starting to come together.
Frontiers in Immunology
7
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10.3389/fimmu.2016.00401
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Patin, Emmanuel, Jones, Adam V., Thompson, Aiysha, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Liao, Chia-Te, Griffiths, James S., Wallace, Leah, Bryant, Clare E., Lang, Roland, Rosenstiel, Philip, Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, Jones, Gareth Wyn and Orr, Selinda Jane
2016.
IL-27 induced by Select Candida spp. via TLR7/NOD2 signaling and IFN-β production inhibits fungal clearance.
The Journal of Immunology
197
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10.4049/jimmunol.1501204
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Liu, Xiang, Jones, Gareth W., Choy, Ernest H. ORCID: https://orcid.org/0000-0003-4459-8609 and Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711
2016.
The biology behind interleukin-6 targeted
interventions.
Current Opinion in Rheumatology
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10.1097/BOR.0000000000000255
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Lacroix, Marine, Rousseau, François, Guilhot, Florence, Malinge, Pauline, Magistrelli, Giovanni, Herren, Suzanne, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Jones, Gareth Wyn, Scheller, Jürgen, Lissilaa, Rami, Kosco-Vilbois, Marie, Johnson, Zoë, Buatois, Vanessa and Ferlin, Walter
2015.
Novel insights into IL-6 cis- and trans-signaling pathways by differentially manipulating the assembly of the IL-6 signaling complex.
Journal of Biological Chemistry
290
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10.1074/jbc.M115.682138
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Jones, Gareth W., Bombardieri, Michele, Greenhill, Claire J., McLeod, Louise, Nerviani, Alessandra, Rocher-Ros, Vidalba, Cardus, Anna, Williams, Anwen S. ORCID: https://orcid.org/0000-0001-6118-020X, Pitzalis, Costantino, Jenkins, Brendan J. and Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711
2015.
Interleukin-27 inhibits ectopic lymphoid-like structure development in early inflammatory arthritis.
Journal of Experimental Medicine
212
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10.1084/jem.20132307
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| Jones, Gareth Wyn, McLeod, Louise, Kennedy, Catherine L., Bozinovski, Steven, Najdovska, Meri and Jenkins, Brendan J. 2015. Imbalanced gp130 signalling in ApoE-deficient mice protects against atherosclerosis. Atherosclerosis 238 (2) , pp. 321-328. 10.1016/j.atherosclerosis.2014.12.037 |
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Greenhill, Claire J., Jones, Gareth Wyn, Nowell, Mari Ann, Newton, Zarabeth, Harvey, Ann K., Moideen, Abdul Nazeer, Collins, Fraser L., Bloom, Anja C., Coll, Rebecca C., Robertson, Avril A. B., Cooper, Matthew A., Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, O'Neill, Luke A., Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711
2014.
Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction.
Arthritis Research and Therapy
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, 419.
10.1186/s13075-014-0419-y
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Pitzalis, Costantino, Jones, Gareth Wyn, Bombardieri, Michele and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711
2014.
Ectopic lymphoid-like structures in infection, cancer and autoimmunity.
Nature Reviews Immunology
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10.1038/nri3700
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Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Fraser, Donald James ORCID: https://orcid.org/0000-0003-0102-9342, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153 and Jones, Gareth Wyn
2014.
Interleukin-6 in renal disease and therapy.
Nephrology Dialysis Transplantation
30
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, pp. 564-574.
10.1093/ndt/gfu233
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Jones, Gareth Wyn, Greenhill, C. J., Williams, J. O., Nowell, Mari Ann, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Jenkins, B. J. and Jones, S. A.
2013.
Exacerbated inflammatory arthritis in response to hyperactive gp130 signalling is independent of IL-17A.
Annals of the Rheumatic Diseases
72
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, pp. 1738-1742.
10.1136/annrheumdis-2013-203771
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Greenhill, Claire J., Jones, Gareth Wyn, Nowell, Mari Ann, Harvey, Ann, Moideen, Abdul Nazeer, Collins, Fraser, Bloom, Anja Constanze, Coll, R., Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, O'Neill, L. A., Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711
2013.
Interleukin 10 control of the inflammasome restricts arthritic bone erosion [Abstract].
Cytokine
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10.1016/j.cyto.2013.06.105
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Orr, Selinda Jane, Burg, Ashley R., Chan, Tim, Quigley, Laura, Jones, Gareth Wyn, Ford, Jill W., Hodge, Deborah, Razzook, Catherine, Sarhan, Joseph, Jones, Yava L., Whittaker, Gillian C., Boelte, Kimberly C., Lyakh, Lyudmila, Cardone, Marco, O'Connor, Geraldine M., Tan, Cuiyan, Li, Hongchuan, Anderson, Stephen K., Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Zhang, Weiguo, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, Trinchieri, Giorgio and McVicar, Daniel W.
2013.
LAB/NTAL facilitates fungal/PAMP-induced IL-12 and IFN-γ production by repressing β-catenin activation in dendritic cells.
PLoS Pathogens
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Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, Heydeck, Dagmar, Jones, Gareth Wyn, Kronke, Gerhard, Funk, Colin D., Knapper, Steven ORCID: https://orcid.org/0000-0002-6405-4441, Adams, Deborah, Kuhn, Hartmut and O'Donnell, Valerie Bridget ORCID: https://orcid.org/0000-0003-4089-8460
2012.
Development of myeloproliferative disease in 12/15-lipoxygenase deficiency [Letter].
Blood
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10.1182/blood-2012-02-410928
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Jones, Gareth Wyn, Greenhill, Claire J., Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Nowell, Mari Ann, Jenkins, Brian J. and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711
2012.
Interleukin-27 receptor-deficient mice develop exacerbated inflammatory arthritis associated with heightened T- and B-cell responses [Abstract].
Rhuematology
51
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10.1093/rheumatology/kes117
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Jones, Gareth Wyn, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Nowell, Mari Ann, Jenkins, Brian J. and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711
2011.
Interleukin-27 receptor-deficient mice develop exacerbated inflammatory arthritis associated with heightened T- and B- cell responses [Abstract].
Arthritis and Rheumatism
63
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10.1002/art.33310
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Jones, Gareth Wyn, Stumhofer, Jason S., Foster, Tom, Twohig, Jason Peter, Hertzog, Paul, Topley, Nicholas, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Hunter, Christopher A., Jenkins, Brendan J., Wang, Edward Chung Yern ORCID: https://orcid.org/0000-0002-2243-4964 and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711
2011.
Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation.
The FASEB Journal
25
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10.1096/fj.10-166843
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Kennedy, Catherine L., Najdovska, Meri, Jones, Gareth Wyn, McLeod, Louise, Hughes, Norman R., Allison, Cody, Huey Ooi, Chia, Tan, Patrick, Ferrero, Richard L., Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Dev, Anouk, Sievert, William, Bhathal, Prithi S. and Jenkins, Brendan J.
2011.
The molecular pathogenesis of STAT3-driven gastric tumourigenesis in mice is independent of IL-17.
The Journal of Pathology
225
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, pp. 255-264.
10.1002/path.2933
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|
Jones, Gareth Wyn, Stumhofer, J. S., Foster, T., Twohig, Jason Peter, Hertzog, P., Topley, Nicholas, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Hunter, Catherine, Jenkins, Brian J., Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Wang, Edward Chung Yern ORCID: https://orcid.org/0000-0002-2243-4964
2010.
Differential responsiveness of naive and activated T cells to TL1A that affect Th17 generation, maintenance and proliferation [Abstract].
Immunology
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Lissilaa, Rami, Buatois, Vanessa, Magistrelli, Giovanni, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Jones, Gareth Wyn, Herren, Suzanne, Shang, Limin, Malinge, Pauline, Guilhot, Florence, Chatel, Laurence, Hatterer, Eric, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Kosco-Vilbois, Marie H. and Ferlin, Walter G.
2010.
Although IL-6 trans-signaling is sufficient to drive local immune responses, classical IL-6 signaling is obligate for the induction of T cell-mediated autoimmunity.
The Journal of Immunology
185
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10.4049/jimmunol.1002015
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Jones, Gareth Wyn, McLoughlin, Rachel Mary, Hammond, Victoria Jayne, Parker, Clare Rhian, Williams, John, Malhotra, Raj, Scheller, Jurgen, Williams, Anwen ORCID: https://orcid.org/0000-0001-6118-020X, Rose-John, Stefan, Topley, Nicholas and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711
2010.
Loss of CD4+ T Cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells.
The Journal of Immunology
184
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10.4049/jimmunol.0901528
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Jones, Gareth Wyn, McLoughlin, R. M., Hammond, Victoria Jayne, Parker, Clare R., Williams, John D., Malhotra, R., Scheller, J., Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Rose-John, Stefan, Topley, Nicholas and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711
2010.
Loss of CD4(+) T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells.
Journal of Immunology
184
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Nowell, Mari Ann, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Carty, Sara Madelaine, Scheller, Jurgen, Hayes, Anthony Joseph, Jones, Gareth Wyn, Richards, Peter James, Slinn, Simon James, Ernst, Matthias, Jenkins, Brendan J., Topley, Nicholas, Rose-John, Stephen and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711
2009.
Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis.
Journal of Immunology
182
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Jones, Gareth Wyn, Stumhofer, J. S., Newton, Zarabeth, Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004, Ernst, M., Topley, Nicholas, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Hunter, Catherine, Jenkins, Brian J., Wang, Edward Chung Yern ORCID: https://orcid.org/0000-0002-2243-4964 and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711
2008.
TL1A/TNFSF15 promotes a STAT1-mediated suppression of IL-17-secreting T-helper cells [Abstract].
Immunology
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10.1111/j.1365-2567.2008.02974.x
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Longhi, Maria Paula, Wright, Kate Louise, Lauder, Sarah Nicol, Nowell, Mari Ann, Jones, Gareth Wyn, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004
2008.
Interleukin-6 is crucial for recall of influenza-specific memory cd4+ t cells.
PLoS Pathogens
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10.1371/journal.ppat.1000006
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Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Jones, Gareth Wyn, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X and Nowell, Mari Ann
2008.
Appreciating the balance between classical interleukin (IL)-6 receptor signaling and IL-6 trans-signaling: implications for arthritis progression.
Immunology Endocrine & Metabolic Agents in Medicinal Chemistry
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