Jones, Simon Arnett  ORCID: https://orcid.org/0000-0001-7297-9711, Fraser, Donald James ORCID: https://orcid.org/0000-0003-0102-9342, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153 and Jones, Gareth Wyn
2014.
Interleukin-6 in renal disease and therapy.
Nephrology Dialysis Transplantation
30
(4)
, pp. 564-574.
10.1093/ndt/gfu233
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Abstract
Interleukin (IL)-6 has become a major target for clinical intervention in various autoimmune conditions. Here, drugs including the humanized anti-IL-6 receptor (IL-6R) antibody tocilizumab emphasize the clinical importance of IL-6 in driving disease and poor patient outcomes. During the course of this review, we will outline the biology surrounding IL-6 and discuss the impact of IL-6 in renal disease and the clinical complications associated with renal replacement therapies and transplantation. We will also consider the merit of IL-6 measurement as a prognostic indicator and provide a clinical perspective on IL-6-blocking therapies in renal disease.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine Research Institutes & Centres > Systems Immunity Research Institute (SIURI) |
| Subjects: | R Medicine > RC Internal medicine |
| Publisher: | Oxford University Press |
| ISSN: | 0931-0509 |
| Funders: | Arthritis Research UK |
| Date of First Compliant Deposit: | 30 March 2016 |
| Date of Acceptance: | July 2014 |
| Last Modified: | 22 Nov 2024 13:30 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/78708 |
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