Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Polypropylene sulfide nanoparticle p24 vaccine promotes dendritic cell-mediated specific immune responses against HIV-1

Caucheteux, Stephan M., Mitchell, John P., Ivory, Matthew O., Hirosue, Sachiko, Hakobyan, Svetlana, Dolton, Garry, Ladell, Kristin, Miners, Kelly, Price, David A., Kan-Mitchell, June, Sewell, Andrew K., Nestle, Frank, Moris, Arnaud, Karoo, Richard O., Birchall, James C., Swartz, Melody A., Hubbel, Jeffrey A., Blanchet, Fabien P. and Piguet, Vincent 2016. Polypropylene sulfide nanoparticle p24 vaccine promotes dendritic cell-mediated specific immune responses against HIV-1. Journal of Investigative Dermatology 136 (6) , pp. 1172-1181. 10.1016/j.jid.2016.01.033

PDF - Accepted Post-Print Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (447kB) | Preview


Delivery of vaccine formulations into the dermis using antigen-coated microneedle patches is a promising and safe approach because of efficient antigen delivery and safety. We evaluated an intradermal vaccine using HIV-1 p24 Gag peptide-conjugated polypropylene sulfide nanoparticles to induce immunity against HIV-1. This peptide-conjugated polypropylene sulfide nanoparticle formulation did not accelerate the maturation of blood- or skin-derived subsets of dendritic cells, either generated in vitro or purified ex vivo, despite efficient uptake in the absence of adjuvant. Moreover, dendritic cell-mediated capture of particulate antigen in this form induced potent HIV-1–specific CD4+ T-cell responses, as well as B-cell–mediated antibody production. Nanoparticle-based intradermal antigen delivery may therefore provide a new option in the global effort to develop an effective vaccine against HIV-1.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: Q Science > QR Microbiology > QR180 Immunology
Uncontrolled Keywords: DC, dendritic cell; ID, intradermal; LC, Langerhans cell; LPS, lipopolysaccharide; MDDC, monocyte-derived dendritic cell; MDLC, monocyte-derived Langerhans cell; NP, nanoparticle; p24, HIV-1 capsid protein; p24NP, HIV-1 p24 Gag peptide-conjugated polypropylene sulfide nanoparticle; TNF, tumor necrosis factor
Additional Information: Released with a Creative Commons Attribution Non-Commercial No Derivatives License (CC BY-NC-ND)
Publisher: Elsevier
ISSN: 0022-202X
Date of First Compliant Deposit: 11 April 2016
Date of Acceptance: 14 January 2016
Last Modified: 24 Nov 2020 14:32

Citation Data

Cited 10 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item


Downloads per month over past year

View more statistics