IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation

Liao, Chia-Te, Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Davies, Luke C., Giles, Peter J. ORCID: https://orcid.org/0000-0003-3143-6854, Tyrrell, Victoria J., O'Donnell, Valerie B. ORCID: https://orcid.org/0000-0003-4089-8460, Topley, Nicholas, Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Fraser, Donald J. ORCID: https://orcid.org/0000-0003-0102-9342, Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711 and Taylor, Philip R. ORCID: https://orcid.org/0000-0003-0163-1421 2016. IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation. European Journal of Immunology 46 (9) , pp. 2222-2232. 10.1002/eji.201646528

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Abstract

The inflammatory activation and recruitment of defined myeloid populations is essential for controlling the bridge between innate and adaptive immunity and shaping the immune response to microbial challenge. However, these cells exhibit significant functional heterogeneity and the inflammatory signals that differentially influence their effector characteristics are poorly characterized. In this study, we defined the phenotype of discrete subsets of effective antigen-presenting cells (APCs) in the peritoneal cavity during peritonitis. When the functional properties of these cells were compared to inflammatory monocyte-derived macrophages we noted differential responses to the immune-modulatory cytokine IL-10. In contrast to the suppressive actions of IL-10 on inflammatory macrophages, the recruitment of APCs was relatively refractory and we found no evidence for selective inhibition of APC differentiation. This differential response of myeloid cell subsets to IL-10 may thus have limited impact on development of potentially tissue-damaging adaptive immune responses, whilst restricting the magnitude of the inflammatory response. These findings may have clinical relevance in the context of peritoneal dialysis patients, where recurrent infections are associated with immune-mediated membrane dysfunction, treatment failure and increased morbidity.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Additional Information:	This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Publisher:	Wiley
ISSN:	0014-2980
Funders:	Medical Research Council, Wellcome Trust
Date of First Compliant Deposit:	11 July 2016
Date of Acceptance:	29 June 2016
Last Modified:	11 Oct 2023 18:44
URI:	https://orca.cardiff.ac.uk/id/eprint/92468

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