Increased oral fibroblast lifespan is telomerase-independent

Enoch, Stuart, Wall, Ivan Bernard, Peake, Matthew Arnold, Davies, Lindsay Catrina ORCID: https://orcid.org/0000-0002-4876-6270, Farrier, Jerry N., Giles, Peter James ORCID: https://orcid.org/0000-0003-3143-6854, Baird, Duncan Martin ORCID: https://orcid.org/0000-0001-8408-5467, Kipling, David Glyn, Price, Patricia Elaine, Moseley, Ryan ORCID: https://orcid.org/0000-0002-2812-6735, Thomas, David William ORCID: https://orcid.org/0000-0001-7319-5820 and Stephens, Philip ORCID: https://orcid.org/0000-0002-0840-4996 2009. Increased oral fibroblast lifespan is telomerase-independent. Journal of Dental Research 88 (10) , pp. 916-921. 10.1177/0022034509342979

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Abstract

Oral mucosal wound-healing is characterized by rapid re-epithelialization and remodeling, with minimal scar formation. This may be attributed to the distinct phenotypic characteristics of the resident fibroblasts. To test this hypothesis, we investigated patient-matched oral mucosal and skin fibroblasts. Compared with skin fibroblasts, oral mucosal fibroblasts had longer proliferative lifespans, underwent more population doublings, and experienced senescence later, which was directly related to longer telomere lengths within oral mucosal fibroblasts. The presence of these longer telomeres was independent of telomerase expression, since both oral oral mucosal fibroblasts and skin fibroblasts were negative for active telomerase, as assessed according to the Telomeric Repeat Amplification Protocol. This study has demonstrated that, compared with skin fibroblasts, oral mucosal fibroblasts are 'younger', with a more embryonic/fetal-like phenotype that may provide a notable advantage for their ability to repair wounds in a scarless fashion.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Dentistry Medicine Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > R Medicine (General) R Medicine > RB Pathology R Medicine > RK Dentistry
Uncontrolled Keywords:	telomeres; fibroblast; aging; oral mucosa
Publisher:	Sage
ISSN:	0022-0345
Last Modified:	06 Nov 2024 22:22
URI:	https://orca.cardiff.ac.uk/id/eprint/15844

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