Analysis of urinary microRNAs in chronic kidney disease

Beltrami, Cristina, Clayton, Aled ORCID: https://orcid.org/0000-0002-3087-9226, Phillips, Aled Owain ORCID: https://orcid.org/0000-0001-9744-7113, Fraser, Donald James ORCID: https://orcid.org/0000-0003-0102-9342 and Bowen, Timothy ORCID: https://orcid.org/0000-0001-6050-0435 2012. Analysis of urinary microRNAs in chronic kidney disease. Biochemical Society Transactions 40 (4) , pp. 875-879. 10.1042/BST20120090

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Abstract

Kidney biopsy is the gold-standard diagnostic test for intrinsic renal disease, but requires hospital admission and carries a 3% risk of major complications. Current non-invasive prognostic indicators such as urine protein quantification have limited predictive value. Better diagnostic and prognostic tests for chronic kidney disease patients are a major focus for industry and academia, with efforts to date directed largely at urinary proteomic approaches. microRNAs constitute a recently identified class of endogenous short non-coding single-stranded RNA oligonucleotides that regulate gene expression post-transcriptionally. Quantification of urinary microRNAs offers an alternative approach to the identification of chronic kidney disease biomarkers.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	biomarker, chronic kidney disease (CKD), exosome, microRNA (miRNA), urine
Publisher:	Biochemical Society
ISSN:	0300-5127
Last Modified:	09 Jun 2023 06:46
URI:	https://orca.cardiff.ac.uk/id/eprint/41949

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