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Online Research @ Cardiff

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Number of items: 53.

Grayling, Michael J. and Mander, Adrian P. 2022. Optimised point estimators for multi-stage single-arm phase II oncology trials. Journal of Biopharmaceutical Statistics 10.1080/10543406.2022.2041656

Grayling, Michael J. and Mander, Adrian P. 2021. Two-stage single-arm trials are rarely analyzed effectively or reported adequately. JCO Precision Oncology 5 , pp. 1813-1820. 10.1200/PO.21.00276

Wilhelm-Benartzi, Charlotte S., Miller, Sarah E., Bruggraber, Sylvaine, Picton, Diane, Wilson, Mark, Gatley, Katrina, Chhabra, Anita, Marcovecchio, M. Loredana, Hendriks, A. Emile J., Morobé, Hilde, Chmura, Piotr Jaroslaw, Bond, Simon, Aschemeier-Fuchs, Bärbel, Knip, Mikael, Tree, Timothy, Overbergh, Lut, Pall, Jaivier, Arnaud, Olivier, Haller, Michael J., Nitsche, Almut, Schulte, Anke M., Mathieu, Chantal, Mander, Adrian and Dunger, David 2021. Study protocol: Minimum effective low dose: anti-human thymocyte globulin (MELD-ATG): phase II, dose ranging, efficacy study of antithymocyte globulin (ATG) within 6 weeks of diagnosis of type 1 diabetes. BMJ Open 11 (12) , e053669. 10.1136/bmjopen-2021-053669

Grayling, Michael J. and Mander, Adrian P. 2021. Accounting for variation in the required sample size in the design of group-sequential trials. Contemporary Clinical Trials 107 , 106459. 10.1016/j.cct.2021.106459

Bennett, Maxine, White, Simon, Best, Nicky and Mander, Adrian 2021. A novel equivalence probability weighted power prior for using historical control data in an adaptive clinical trial design: a comparison to standard methods. Pharmaceutical Statistics 20 (3) , pp. 462-484. 10.1002/pst.2088

Law, Martin, Grayling, Michael J. and Mander, Adrian P. 2021. A stochastically curtailed two‐arm randomised phase II trial design for binary outcomes. Pharmaceutical Statistics 20 (2) , pp. 212-228. 10.1002/pst.2067

Dimairo, Munyaradzi, Pallmann, Philip, Wason, James, Todd, Susan, Jaki, Thomas, Julious, Steven A, Mander, Adrian P, Weir, Christopher J, Koenig, Franz, Walton, Marc K, Nicholl, Jon P, Coates, Elizabeth, Biggs, Katie, Hamasaki, Toshimitsu, Proschan, Michael A, Scott, John A, Ando, Yuki, Hind, Daniel and Altman, Douglas G 2020. The Adaptive designs CONSORT Extension (ACE) Statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design. BMJ 369 , m115. 10.1136/bmj.m115

Dimairo, Munyaradzi, Pallmann, Philip, Wason, James, Todd, Susan, Jaki, Thomas, Julious, Steven A., Mander, Adrian P., Weir, Christopher J., Koenig, Franz, Walton, Marc K., Nicholl, Jon P., Coates, Elizabeth, Biggs, Katie, Hamasaki, Toshimitsu, Proschan, Michael A., Scott, John A., Ando, Yuki, Hind, Daniel and Altman, Douglas G. 2020. The Adaptive designs CONSORT Extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design. Trials 21 , 528. 10.1186/s13063-020-04334-x

Pallmann, Philip, Wan, Fang, Mander, Adrian P, Wheeler, Graham M, Yap, Christina, Clive, Sally, Hampson, Lisa V and Jaki, Thomas 2020. Designing and evaluating dose-escalation studies made easy: the MoDEsT web app. Clinical Trials 17 (2) , pp. 147-156. 10.1177/1740774519890146

Bennett, Maxine and Mander, Adrian P. 2020. Designs for adding a treatment arm to an ongoing clinical trial. Trials 21 (1) , 251. 10.1186/s13063-020-4073-1

Grayling, Michael J, Dimairo, Munyaradzi, Mander, Adrian P and Jaki, Thomas F 2019. A review of perspectives on the use of randomization in phase II oncology trials. JNCI: Journal of the National Cancer Institute 111 (12) , pp. 1255-1262. 10.1093/jnci/djz126

Wych, Julie, Grayling, Michael J. and Mander, Adrian P. 2019. Sample size re-estimation in crossover trials: application to the AIM HY-INFORM study. Trials 20 (1) , 665. 10.1186/s13063-019-3724-6

Dimairo, Munya, Pallmann, Philip, Wason, James, Todd, Sue, Jaki, Thomas, Julious, Steven A., Mander, Adrian, Weir, Christopher J., Koenig, Franz, Walton, Marc K., Nicholl, Jon P., Coates, Elizabeth, Biggs, Katie, Hamasaki, Toshimitsu, Proschan, Michael A., Scott, John A., Ando, Yuki, Hind, Daniel and Altman, Douglas G. 2019. Introducing the Adaptive designs CONSORT Extension (ACE) Statement to improve reporting of randomised trials that use an adaptive design (P-7). Presented at: 5th International Clinical Trials Methodology Conference (ICTMC 2019), Brighton, UK, 6-9 October 2019. BioMed Central, -. 10.1186/s13063-019-3688-6

Grayling, Michael J., Mander, Adrian P. and Wason, James M. S. 2019. Two-stage adaptive designs for three-treatment bioequivalence studies. Statistics in Biopharmaceutical Research 11 (4) , pp. 360-374. 10.1080/19466315.2019.1654911

Grayling, Michael J., Wason, James M. S. and Mander, Adrian P. 2019. Exact group sequential designs for two-arm experiments with Poisson distributed outcome variables. Communications in Statistics - Theory and Methods 50 (1) , pp. 18-34. 10.1080/03610926.2019.1628273

Grayling, Michael J., Mander, Adrian P. and Wason, James M. S. 2019. Admissible multiarm stepped-wedge cluster randomized trial designs. Statistics in Medicine 38 (7) , pp. 1103-1119. 10.1002/sim.8022

Wheeler, Graham M., Sweeting, Michael J. and Mander, Adrian P. 2019. A Bayesian model‐free approach to combination therapy phase I trials using censored time‐to‐toxicity data. Journal of the Royal Statistical Society: Series C 68 (2) , pp. 309-329. 10.1111/rssc.12323

Wheeler, Graham M., Sweeting, Michael J. and Mander, Adrian P. 2017. Toxicity-dependent feasibility bounds for the escalation with overdose control approach in phase I cancer trials. Statistics in Medicine 36 (16) , pp. 2499-2513. 10.1002/sim.7280

Wheeler, Graham M., Sweeting, Michael J., Mander, Adrian P., Lee, Shing M. and Cheung, Ying Kuen K. 2017. Modelling semi-attributable toxicity in dual-agent phase I trials with non-concurrent drug administration. Statistics in Medicine 36 (2) , pp. 225-241. 10.1002/sim.6912

Spencer, Amy V., Harbron, Chris, Mander, Adrian, Wason, James and Peers, Ian 2016. An adaptive design for updating the threshold value of a continuous biomarker. Statistics in Medicine 35 (27) , p. 4909. 10.1002/sim.7042

Mander, Adrian P. and Sweeting, Michael J. 2015. A product of independent beta probabilities dose escalation design for dual-agent phase I trials. Statistics in Medicine 34 (8) , 1261--1276. 10.1002/sim.6434

Walker, Celia G, Holzapfel, Christina, Loos, Ruth J F, Mander, Adrian P, Klopp, Norman, Illig, Thomas, Caterson, Ian D, Hauner, Hans and Jebb, Susan A 2013. Genetic predisposition to an adverse lipid profile limits the improvement in total cholesterol in response to weight loss. Obesity 21 (12) , pp. 2589-95. 10.1002/oby.20328

Sweeting, Michael, Mander, Adrian and Sabin, Tony 2013. bcrm: Bayesian Continual Reassessment Method designs for Phase I dose-finding trials. Journal of Statistical Software 54 (13) 10.18637/jss.v054.i13

Harrington, Jennifer A., Wheeler, Graham M., Sweeting, Michael J., Mander, Adrian P. and Jodrell, Duncan I. 2013. Adaptive designs for dual-agent phase I dose-escalation studies. Nature Reviews Clinical Oncology 10 (5) , pp. 277-288. 10.1038/nrclinonc.2013.35

Browning, Lucy M., Walker, Celia G., Mander, Adrian P., West, Annette L., Madden, Jackie, Gambell, Joanna M., Young, Stephen, Wang, Laura, Jebb, Susan A. and Calder, Philip C. 2012. Incorporation of eicosapentaenoic and docosahexaenoic acids into lipid pools when given as supplements providing doses equivalent to typical intakes of oily fish. American Journal of Clinical Nutrition 96 (4) , pp. 748-758. 10.3945/ajcn.112.041343

Sweeting, Michael J. and Mander, Adrian P. 2012. Escalation strategies for combination therapy Phase I trials. Pharmaceutical Statistics 11 (3) , pp. 258-266. 10.1002/pst.1497

Wason, James M. S. and Mander, Adrian P. 2012. Minimizing the Maximum Expected Sample Size in Two-Stage Phase II Clinical Trials with Continuous Outcomes. Journal of Biopharmaceutical Statistics 22 (4) , pp. 836-852. 10.1080/10543406.2010.528104

Walker, Celia G., Loos, Ruth J. F., Mander, Adrian P., Jebb, Susan A., Frost, Gary S., Griffin, Bruce A., Lovegrove, Julie A., Sanders, Thomas A. B. and Bluck, Les J. 2012. Genetic predisposition to type 2 diabetes is associated with impaired insulin secretion but does not modify insulin resistance or secretion in response to an intervention to lower dietary saturated fat. Genes and Nutrition 7 (4) , pp. 529-536. 10.1007/s12263-012-0284-8

Mander, Adrian P., Wason, James M. S., Sweeting, Michael J. and Thompson, Simon G. 2012. Admissible two-stage designs for phase II cancer clinical trials that incorporate the expected sample size under the alternative hypothesis. Pharmaceutical Statistics 11 (2) , pp. 91-96. 10.1002/pst.501

Mander, A. P., Ahern, A. L., Caterson, I. D., Hauner, H. and Jebb, S. A. 2012. Weight loss in a commercial setting: Authors' reply. Lancet 379 (9820) , p. 1003. 10.1016/S0140-6736(12)60425-5

Wason, James M. S., Mander, Adrian P. and Thompson, Simon G. 2012. Optimal multistage designs for randomised clinical trials with continuous outcomes. Statistics in Medicine 31 (4) , pp. 301-312. 10.1002/sim.4421

Jebb, Susan A., Ahern, Amy L., Olson, Ashley D., Aston, Louise M., Holzapfel, Christina, Stoll, Julia, Amann-Gassner, Ulrike, Simpson, Annie E., Fuller, Nicholas R., Pearson, Suzanne, Lau, Namson S., Mander, Adrian P., Hauner, Hans and Caterson, Ian D. 2011. Primary care referral to a commercial provider for weight loss treatment versus standard care: a randomised controlled trial. Lancet 378 (9801) , pp. 1485-1492. 10.1016/S0140-6736(11)61344-5

Thompson, Simon, Ekelund, Ulf, Jebb, Susan, Lindroos, Anna Karin, Mander, Adrian, Sharp, Stephen, Turner, Rebecca and Wilks, Desiree 2011. A proposed method of bias adjustment for meta-analyses of published observational studies. International Journal of Epidemiology 40 (3) , pp. 765-777. 10.1093/ije/dyq248

Wason, James M. S., Mander, Adrian P. and Eisen, Tim G. 2011. Reducing sample sizes in two stage phase II cancer trials by using continuous tumour shrinkage end-points. European Journal of Cancer 47 (7) , pp. 983-989. 10.1016/j.ejca.2010.12.007

Wilks, Desiree C., Sharp, Stephen J., Ekelund, Ulf, Thompson, Simon G., Mander, Adrian P., Turner, Rebecca M., Jebb, Susan A. and Lindroos, Anna Karin 2011. Objectively measured physical activity and fat mass in children: A bias-adjusted meta-analysis of prospective studies. PLoS ONE 6 (2) , e17205.. 10.1371/journal.pone.0017205

Wilks, Desiree C., Mander, Adrian P., Jebb, Susan A., Thompson, Simon G., Sharp, Stephen J., Turner, Rebecca M. and Lindroos, Anna Karin 2011. Dietary energy density and adiposity: Employing bias adjustments in a meta-analysis of prospective studies. BMC Public Health 11 , -. 10.1186/1471-2458-11-48

da Costa, Teresa H. M., Haisma, Hinke, Wells, Jonathan C. K., Mander, Adrian P., Whitehead, Roger G. and Bluck, Leslie J. C. 2010. How much human milk do infants consume? Data from 12 countries using a standardized stable isotope methodology. Journal of Nutrition 140 (12) , pp. 2227-2232. 10.3945/jn.110.123489

Bluck, Leslie J. C., Jackson, Sarah J., Vlasakakis, Georgios and Mander, Adrian 2010. Bayesian hierarchical methods to interpret the C-13-octanoic acid breath test for gastric emptying. Digestion 83 (1-2) , pp. 96-107. 10.1159/000316823

Mander, A. P. and Thompson, S. G. 2010. Two-stage designs optimal under the alternative hypothesis for phase II cancer clinical trials. Contemporary Clinical Trials 31 (6) , pp. 572-578. 10.1016/j.cct.2010.07.008

Cook, Natalie, Basu, Bristi, Biswas, Swethajit, Kareclas, Paula, Mann, Colette, Palmer, Cheryl, Thomas, Anne, Nicholson, Steve, Morgan, Bruno, Lomas, David, Sirohi, Bhawna, Mander, Adrian P., Middleton, Mark and Corrie, Pippa G. 2010. A phase 2 study of vatalanib in metastatic melanoma patients. European Journal of Cancer 46 (15) , pp. 2671-2673. 10.1016/j.ejca.2010.07.014

Aston, L. M., Laccetti, R., Mander, Adrian P., Hall, R., Moore, C.S. and Jebb, S.A. 2010. No difference in the 24-hour interstitial fluid glucose profile with modulations to the glycemic index of the diet. Nutrition 26 (3) , pp. 290-295. 10.1016/j.nut.2009.05.010

Aston, Louise M., Laccetti, Roberta, Mander, Adrian P., Hall, Rosemary, Moore, Carmel S. and Jebb, Susan A. 2010. No difference in the 24-hour interstitial fluid glucose profile with modulations to the glycemic index of the diet. Nutrition 26 (3) , pp. 290-295. 10.1016/j.nut.2009.05.010

Siervo, M., Corander, M., Mander, A. P., Browning, L. M. and Jebb, S. A. 2010. Acute effects of hyperglycaemia on asymmetric dimethylarginine (ADMA), adiponectin and inflammatory markers (IL-6, hs-CRP) in overweight and obese women with metabolic syndrome. British Journal of Biomedical Science 67 (4) , pp. 216-218. 10.1080/09674845.2010.11730322

Sripanyakorn, Supannee, Jughaohsingh, Ravin, Mander, Adrian, Davidson, Sarah L., Thompson, Richard P. H. and Powell, Jonathan J. 2009. Moderate ingestion of alcohol is associated with acute ethanol-induced suppression of circulating CTX in a PTH-independent fashion. Journal of Bone and Mineral Research 24 (8) , pp. 1380-1388. 10.1359/JBMR.090222

Wilks, D. C., Mander, Adrian P., Jebb, S. A., Thompson, S.G., Sharp, S., Turner, R. M. and Lindroos, A.K. 2009. Dietary energy density and weight gain: A bias-adjusted meta-analysis of prospective studies [Poster Abstract]. Obesity 17 (S2) , S314. 10.1038/oby.2009.286

Prynne, C. J., Mander, A., Wadsworth, M. E. J. and Stephern, A. M. 2009. Diet and glycosylated haemoglobin in the 1946 British birth cohort. European Journal of Clinical Nutrition 63 (9) , pp. 1084-1090. 10.1038/ejcn.2009.43

Chatfield, Mark and Mander, Adrian 2009. The Skillings-Mack test (Friedman test when there are missing data). Stata Journal 9 (2) , pp. 299-305. 10.1177/1536867X0900900208

Cunnington, Marianne, Webb, David, Qizilbash, Nawab, Blum, David, Mander, Adrian, Jonsson Funk, Michele and Weil, John 2008. Risk of ischaemic cardiovascular events from selective cyclooxygenase-2 inhibitors in osteoarthritis. Pharmacoepidemiology and Drug Safety 17 (6) , pp. 601-608. 10.1002/pds.1590

Johnson, L., Mander, A. P., Jones, L. R., Emmett, P. M. and Jebb, S. A. 2008. A prospective analysis of dietary energy density at age 5 and 7 years and fatness at 9 years among UK children. International Journal of Obesity 32 (4) , pp. 586-593. 10.1038/sj.ijo.0803746

Johnson, Laura, Mander, Adrian, Jones, Louise R., Emmett, Pauline M. and Jebb, Susan A. 2008. Energy-dense, low-fiber, high-fat dietary pattern is associated with increased fatness in childhood. American Journal of Clinical Nutrition 87 (4) , pp. 846-854. 10.1093/ajcn/87.4.846

Mander, A. P. and Bansal, A. 2006. Stepwise haplotype analysis: are LD patterns repeatable? Human Genomics 2 (6) , 376. 10.1186/1479-7364-2-6-376

Henseik, A. E., Sawcer, S. J., Feakes, R., Deans, J., Mander, A., Akesson, E., Roxburgh, R., Coraddu, F., Smith, S. and Compston, D. A. S. 2002. HLA-DR 15 is associated with female sex and younger age at diagnosis in multiple sclerosis. Journal of Neurology, Neurosurgery and Psychiatry 72 (2) , pp. 184-187. 10.1136/jnnp.72.2.184

Meyers, A, Marshall, H, Nowotny, P, Smemo, S, Mander, A, Holmans, P., Ertekin-Taner, N., Ronald, J., Younkin, S., Tucker, H. M., Estus, S., Crook, R., Hardy, J., Dunstan, M., Hamshere, M., O'Donovan, M., Jones, L., Williams, J. and Owen, M. J. 2002. INFORMATION REQUESTED Follow-up of replicated linkage results on chromosome 10: Putative role of the urokinase plasminogen activator gene in risk for late-onset Alzheimer's disease. Neurobiology of Aging 23 (1) , S310.

This list was generated on Tue Jul 5 08:14:18 2022 BST.