ORCA
Online Research @ Cardiff
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Moon, Owen R., Newman, Andrew C., Alanazi, Abdullah S., Wehenkel, Sophie C., Gawel-Bęben, Katarzyna, Ivetic, Aleksandar, Price, David A.  ORCID: https://orcid.org/0000-0001-9416-2737, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924 and Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908
2025.
TCR activation stimulates regulated intramembrane proteolysis of L-selectin by presenilin 1 and localized proteasomal degradation of the cytoplasmic tail.
Journal of Biological Chemistry
301
(8)
, 110473.
10.1016/j.jbc.2025.110473
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Demaria, Maria C., Yeung, Louisa, Peeters, Rens, Wee, Janet L., Mihaljcic, Masa, Jones, Eleanor L., Nasa, Zeyad, Alderuccio, Frank, Hall, Pamela, Smith, Brodie C., Hammerling, Gunther, Kwok, Hang Fai, Newman, Andrew, Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, van Spriel, Annemiek, Hickey, Michael J. and Wright, Mark D.
2020.
Tetraspanin CD53 promotes lymphocyte recirculation by stablising L-selectin surface expression.
iScience
23
(5)
, 101104.
10.1016/j.isci.2020.101104
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Mohammed, Rebar N., Wehenkel, Sophie C., Galkina, Elena V., Yates, Emma-Kate, Preece, Graham, Newman, Andrew, Watson, H. Angharad, Ohme, Julia, Bridgeman, John S., Durairaj, Ruban R. P., Moon, Owen R., Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Miners, Kelly L., Dolton, Garry, Troeberg, Linda, Kashiwagi, Masahide, Murphy, Gillian, Nagase, Hideaki, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Matthews, R. James, Knauper, Vera ORCID: https://orcid.org/0000-0002-3965-9924 and Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908
2019.
ADAM17-dependent proteolysis of L-selectin promotes early clonal expansion of cytotoxic T cells.
Scientific Reports
9
, 5487.
10.1038/s41598-019-41811-z
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Newman, Andrew
2017.
The regulation of L-selectin activity by proteolysis.
PhD Thesis,
Cardiff University.
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